复方丙酸氯倍他索软膏治疗寻常性银屑病临床疗效观察

Efficacy of clobetasol propionate compound ointment for the treatment of psoriasis vulgaris

目的:观察复方丙酸氯倍他索软膏治疗寻常性银屑病的疗效和安全性。方法:将入组的360例寻常性银屑病患者分为治疗组(复方丙酸氯倍他索软膏组120例)、对照1组(0.02%丙酸氯倍他索霜组120例)和对照2组(0.05%全反式维A酸霜组120例),采用多中心、随机双盲、平行对照的方法对寻常性银屑病患者连续用药4周。结果:3组患者的痊愈率分别为48.33%、18.33%和3.48%,有效率分别为92.50%、50.83%和31.30%。组间比较(试验组与对照1组比较,试验组与对照2组比较)显示,痊愈率和有效率差异均有显著性(P<0.01)。试验组和对照1组的不良反应发生率较轻微,对照2组不良反应发生率为11.67%,有3例因不良反应较重中途停止治疗。结论:复方丙酸氯倍他索软膏是一种安全有效的治疗寻常性银屑病的外用药,其疗效优于单用丙酸氯倍他索霜或全反式维A酸霜。

Objective: To evaluate the efficacy and reliability of clobetasol propionate compound ointment for the treatment of psoriasis vulgaris. Methods: A multicenter randomized double-blind control clinical study was carry out. 360 patients with psoriasis vulgaris were divided into three groups and treated for four weeks. Group A (treatment group) was treated with clobetasol propionate compound ointment therapy, group B (control group 1) with 0.02% clobetasol propionate cream and group C (control group 2) with 0.05% all-trans-retinoic acid cream. Results: The curative rates were 48.33% for group A?18.33% for group B and 3.48% for group C. The efficacy rates were 92.50%? 50.83% and 31.30%, respectively. Incomparison between treatment group and control groups there was statistical difference (P < 0.01) in the curative rates and efficacy rates. In the treatment group and control group 1 only mild side effects were found, and side effects were found in 11.67% patients of control group 2, three of them had to stop their therapy. Conclusions: Clobetasol propionate compound ointment is an effective and safe topical agent for the treatment of psoriasis vulgaris, and its efficacy is better than that of 0.02% clobetasol propionate cream and 0.05% all-trans-retinoic acid cream alone.