低度恶性中央性骨肉瘤

Low-grade central osteosarcoma: a report of 2 cases and review of literature

目的 探讨低度恶性中央性骨肉瘤的临床及病理特征。方法 对 2例低度恶性中央性骨肉瘤进行病理形态学观察和免疫组化分析。结果 2例肿瘤均为复发病例 ,发病年龄分别为 4 6岁和 5 7岁。影像学上肿瘤为发生于骨髓腔内的体积较大、边界清楚的肿物。组织学上肿瘤由纤维及骨组织构成 ,细胞分化良好 ,核分裂象少见。免疫表型示Vim阳性 ,SMA局灶阳性。结论 低度恶性中央性骨肉瘤是骨肉瘤的一种特殊类型 。

Purpose To investigate the clinicopathological characteristics of low-grade central osteosarcoma. Methods Two cases were analyzed at light microscopic level and studied by immunohistochemical staining . Results Two cases were all recurrent old adults. Radiographsically the tumors were large with sharp-cut margins. They arose centrally from the medullary cavity. Histologically, the tumors were composed of spindle cells with only minimal atypia, mitotic figures scarcely, accompanied with neoplastic bone formation. Immunohistochemistry revealed vimentin positive, SMA focal positive. Conclusions Low-grade central osteosarcoma is a special variety. Histologic and radiographic appearance plays important roles in diagnosis of this disease.