胸腺瘤免疫组化研究

Immunihistochemical Study on Thymoma

使用17种抗体对20例胸腺瘤进行免疫组化标记,结果显示:6例上皮型胸腺瘤中,3例为癌胚抗原(CEA)、Keratin、EMA阳性;2例为FN、Vimentin和A_1-AT阳性;1例为NSE和S-100蛋白质阳性。11例淋巴细胞型胸腺瘤中,8例为MB_2和免疫球蛋白轻、重链阳性。3例混合型胸腺瘤中,2例为NSE和S-100蛋白质阳性;1例Vimentin和FN阳性;淋巴细胞均为多克隆性。因此,本文提出对胸腺瘤免疫标记的研究及其重新分类是必要的。

Immunoperoxidese stainings with 17 kinds of antibodies were studied in 20 cases of thymomas. Of the 6 epithelial thymomas,we found theat there were 3 cases of CEA Keratin. EMA positive,2 cases of FN Vimentin and A_1—AT positive, and 1 case of NSE S—100 protein positive. Eight cases were MB_2 amd Ig lighe/heavy chains positivein 11 cases of the lympocyte thymomas, and 2 cases were NSE S-100 protein positive, as well as 1 caseof Vimentin FN positive in 3 cases of the mixed thymomas. Therefore.we concluded that thymoma should be studied with immunoperoxidase staining and reclassified.