门静脉高压症胃黏膜血管内皮生长因子变化的研究

Changes of vascular endothelial growth factor in gastric mucosa in portal hypertensive gastropathy

目的探讨血管内皮生长因子 (VEGF)在门静脉高压症胃病 (PHG)中的作用。方法采用逆转录聚合酶链式反应 (RT PCR)分析 4 4例肝硬化门静脉高压症患者PHG病变部位VEGFmRNA的变化。结果轻度PHG胃黏膜VEGFmRNA表达明显升高 (2 2 8± 0 33) ,与无PHG者(1 5 1± 0 32 )及对照组 (1 4 0± 0 2 3)比较差异均有显著意义 (P <0 0 1) ,重度PHGVEGFmRNA表达进一步增强 (3 4 8± 1 0 2 ) ,与轻度PHG者比较差异亦有显著意义 (P <0 0 1)。结论VEGF过度表达可能是造成PHG时胃黏膜损害的重要因素之一。

Objective To study the role of VEGF in the development of portal hypertensive gastropathy(PHG). Methods Forty-four portal hepertensive patients were investigated according to with or without PHG. The degree and the location of PHG were recorded. The specimens were obtained to perform RT-PCR to measure VEGF mRNA. Results VEGF mRNA in severe (3.48±1.02) or moderate PHG (2.28±0.33) with portal hypertension was higher than that in control (1.40±0.23) and those (1.51±0.32) with portal hypertension without PHG( P <0.01). Conclusions Portal hypertensive gastric mucosa may trigger a high concentration of VEGF mRNA,VEGF in return may play an important role in further development of PHG.