生长激素对脑瘫患儿选择性脊神经切断术后血浆蛋白质代谢的影响

The effects of rhGH on the plasma protein after selective pasterior rhizotomy in patients with cerebral palsy

目的 观察脑瘫患儿选择性脊神经切断 (SPR)手术后血浆蛋白的变化 ,探讨重组人生长激素 (rhGH)对手术以后营养的治疗效果。方法 选择 6 3例行SPR手术的脑瘫患儿作为研究对象 ,将这组患者随机分为对照组 33例及rhGH组 30例 ,两组术后治疗和支持方案相同 ,术后 4 8h开始加用rhGH 0 .1U·(kg/d) - 1 皮下注射 ,连续 4～ 5d。观察两组患儿术后 8～ 9d血浆白蛋白、前白蛋白浓度、血红蛋白水平。结果 两组患者手术后血浆白蛋白水平均有明显降低 ,治疗干预后rhGH组血浆前白蛋白水平显著上升。结论 术后早进食及短期rhGH治疗有利于改善脑瘫患儿SPR手术后的营养状况。

Objective To detecte the changes in plasma protein in the patients with cerebral palsy after selective posterior rhizotomy(SPR) and to evaluate the influence of low dose rhGH on nutrition status of postoperative patients.Methods 63 patients with cerebral palsy requiring SPR were randomly distributed into 2 groups: study group (n=30) and control group (n=33). After operation,study group was given 0.1 U·(kg/d) -1 rhGH for 4-5 days, and then detected plasma albumin and pre-albumin on the 8th after operation.Results The concentration of palsp albumin in all patients was decreased,and in the study group the concentration of prealbumin was increased on the 8th after operation.Conclusion Low dose rhGH can accelerate plasma protein synthesis to improve the nutrition status of postoperative patients.