男性精神分裂症患者海马磁共振质子波谱成像的研究

A H^1 magnetic resonance spectroscopy imaging study on hippocampus in male patients with schizophrenia

目的 探讨精神分裂症患者双侧海马的磁共振质子波谱(MRS)的特点,以期对此疾病的临床诊断提供代谢方面依据,为精神分裂症的病因学探讨提供线索。方法 应用MRS成像技术,对20例男性精神分裂症患者和20名男性正常人检测双侧海马的氮-乙酰天门冬氨酸复合物(NAA)、胆碱复合物(CHO)和肌酸-磷酸肌酸复合物(Cr)含量,对NAA/Cr和CHO/Cr的比值进行计算。以重复测量方差分析的方法进行统计分析,其中组别作为组间差异,左右侧作为组内差异。结果 CHO/Cr的比值在精神分裂症患者双侧海马(左侧为1.03±0.22,右侧为1.00±0.23)高于正常人(左侧为0.95±0.16,右侧为0.97±0.16),差异有显著性(F=6.896,P=0.013);而NAA/Cr的比值在精神分裂症患者与正常人间的差异无显著性(患者左侧为1.29±0.16,右侧为1.25±0.13;正常人左侧为1.41±0.20,右侧为1.36±0.17)。结论 男性精神分裂症患者的海马可能存在膜的磷脂代谢异常。

Objective This study measured N-acetylaspartate ( NAA) , choline ( CHO) and creatine (Cr) in hippocampal regions of patients with schizophrenia using in vivo proton magnetic resonance spectroscopy imaging (H1 MRSI). Methods H1 MRSI were performed on the right and left hippocampal regions in 20 male patients with schizophrenia and 20 normal men. The ratios of NAA/Cr and CHO/Cr were determined. Repeated measures analysis of variance ( ANOVA) was used to test for group differences, with group as between-subjects factor and side as within-subjects factor. Results The CHO/Cr ratio in patients (left: 1. 03±0. 22; right: 1. 00 ±0.23) was significant higher than that in normal controls (left: 0. 95± 0.16; right: 0. 97±0.16) ( F = 6. 896, P = 0. 013). The NAA/Cr ratio had no significantly difference between both groups ( patients, left: 1. 29 ± 0. 16; right: 1. 25± 0. 13 ; control, left: 1. 41± 0. 20; right: 1. 36 ±0. 17). Conclusion Abnormal turnover of membrane phospholipid might exist in hippocampus in male patients with schizophrenia.