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脑血管病变与阿尔茨海默病关系的研究进展 被引量:6

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摘要 阿尔茨海默病(Alzheimer′s disease,AD)是一种中枢神经系统进行性的退行性病变.其病因与遗传、病毒感染、炎症、铝中毒、胆碱系统功能缺陷、细胞骨架改变等有关.近年来的流行病学及病理学研究表明,AD与血管因素有关联.血管因素不仅会造成血管性痴呆(vascular dementia,VD),也可能参与AD的病理生理机制,增加AD的患病风险.
出处 《中华精神科杂志》 CAS CSCD 北大核心 2004年第2期121-123,共3页 Chinese Journal of Psychiatry
基金 国家自然科学基金资助项目(30170327) 上海联合利华研究与发展基金资助项目(145)
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参考文献17

  • 1Kalaria RN. Small vessel disease and Alzheimer′s dementia: pathological considerations. Cerebrovasc Dis, 2002, 13 Suppl 2:48-52.
  • 2Stewart R. Cardiovascular factors in Alzheimer′s disease. J Neurol Neurosurg Psychiatry, 1998, 65:143-147.
  • 3Leibson CL, Rocca WA, Hanson VA, et al. The risk of dementia among persons with diabetes mellitus: a population-based cohort study. Ann N Y Acad Sci, 1997, 826:422-427.
  • 4Marx J. Alzheimer′s disease. Bad for the heart, bad for the mind? Science, 2001, 294:508-509.
  • 5Almeida OP, Hulse GK, Lawrence D, et al. Smoking as a risk factor for Alzheimer′s disease: contrasting evidence from a systematic review of case-control and cohort studies. Addiction, 2002, 97:15-28.
  • 6Sparks DL, Martin TA, Gross DR, et al. Link between heart disease, cholesterol, and Alzheimer′s disease: a review. Microsc Res Tech, 2000, 50:287-290.
  • 7Jellinger KA. Alzheimer disease and cerebrovascular pathology: an update. J Neural Transm, 2002, 109:813-836.
  • 8Olichney JM, Hansen LA, Hofstetter CR, et al. Association between severe cerebral amyloid angiopathy and cerebrovascular lesions in Alzheimer disease is not a spurious one attributable to apolipoprotein E4. Arch Neurol, 2000, 57:869-874.
  • 9de la Torre JC. Critically attained threshold of cerebral hypoperfusion: the CATCH hypothesis of Alzheimer′s pathogenesis. Neurobiol Aging, 2000, 21:331-342.
  • 10Bengtsson K, Orho-Melander M, Lindblad U, et al. Polymorphism in the angiotensin converting enzyme but not in the angiotensinogen gene is associated with hypertension and type 2 diabetes: the Skaraborg Hypertension and diabetes project. J Hypertens, 1999,

二级参考文献25

  • 1顾牛范,冯国鄞,江三多,钱伊萍,林嗣萃,吴晓东,任大明,江开达.中国汉族人群APOE等位基因频率的初步研究[J].中华医学遗传学杂志,1996,13(1):8-10. 被引量:26
  • 2鄢盛恺,周新,哈黛文.聚合酶链反应限制性片段长度多态性检测载脂蛋白E基因型[J].中华医学检验杂志,1997,20(1):28-31. 被引量:60
  • 3Pasquier F, Henon H, Leys D. Relevance of white matter changes to pre- and poststroke dementia. Ann N Y Acad Sci, 2000, 903(2):466 - 469.
  • 4Leys D, Englund E, Del Ser T, et al. White matter changes in stroke patients. Relationship with stroke subtype and outcome. Eur Neurol,1999, 42(1): 67-75.
  • 5Regeur L. Increasing loss of brain tissue with increasing dementia: a stereological study of post- mortem brains from elderly females. Eur J Neurol, 2000, 7(1): 47-54.
  • 6Double KL, Halliday GM, Kril JJ, et al. Topography of brain atrophy during normal aging and Alzheimer' s disease. Neurobiol Aging, 1996,17(4): 513 - 521. [5]Filley CM. The behavioral neurology of cerebral white matter. Neurology, 1998, 50(6): 1535- 1540.
  • 7Esiri MM Which vascular lesions are of importance in vascular dementia?Ann N Y Acad Sci, 2000, 903(1): 239-243.
  • 8Hargrave R, Geck LC, Reed B, et al. Affective behavioural disturbances in Alzheimer' s disease and ischaemic vascular disease. J Neurol Neurosurg Psychiatry, 2000, 68( 1 ): 41 - 46.
  • 9Parnetti L. Pathophysiology of vascular dementia and white matter changes. Rev Neurol, 1999, 155(9): 754-758.
  • 10Breteler MM, Van Swieten JC, Bots ML et al. Cerebral white matter lesions, vascular risk factors, and cognitive function in a population -based study: the Rotterdam study. Neurology, 1994, 44(7): 1246-1252.

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