脂质体载药的稳定性和靶向性研究

Study on Stability and Target of Liposomes as Drug Carriers

稳定性和靶向性是脂质体载药研究中两重要问题,当膜表面电荷与药物离子电性相反时,以及水溶性药物疏水衍生化后脂质体载药的稳定性提高,制备的免疫脂质体体外试验证明有显著靶向性。

The stability were improved by following methodes; Surface charge of liposomes was opposed to the ioaic charge of drug; Hydrophobic modification of water soluble drug.The target was demonstrated in vitro by immunoliposomes.