红曲霉固态发酵产Lovastatin的培养条件

Solid-state Fermentation for Lovastatin Production by Monascus rubber

对 1株红色红曲霉固态发酵产Lovastatin的培养条件进行了研究。得出固态基质最佳初始含水量为 40 %,基础基质中加入葡萄糖和有机氮源能显著提高发酵产物中Lovastatin含量 ,多种蔬菜浸出汁都能提高Lovastatin产量 ,红曲米浸泡水对Lovastatin有明显的促进作用。稻米的种类及米的粉碎度对Lovastatin的合成也有一定的影响。在优化的培养条件下 ,干曲中Lovastatin的含量可以达到 2 5～ 3 0mg/g。

The cultivation conditions for solid state fermentation for producing lovastatin by Monascus ruber were studied The optimal initial water content of substrate was 40% Steamed rice was used as basic substrate and glucose and organic nitrogen resources should be supplemented to increase the lovastatin productivity Extract of red koji and other natural materials such as tomato juice were able to promote the production of lovastatin The breeds of rice and the particle size of rice also affected the production of lovastatin At optimized culture conditions, the productivity of lovastatin in dried koji was 2 5～3 0?mg/L