Ku80蛋白在乳腺癌组织中的表达及其临床意义

The Expression and Significance of Ku80 in the Tissue ofBreast Carcinoma

研究Ku80蛋白在乳腺癌的表达及与临床病理特征的关系。方法:采用免疫组化法检测65例乳腺癌组织Ku80、ER、PR、HER-2和突变型p53表达水平。结果:65例乳腺癌标本中Ku80、ER、PR、HER-2、p53阳性率分别为78.5%、40.0%、53.8%、44.6%和32.3%。Ku80表达水平与肿瘤大小、ER、PR、HER-2和p53的表达水平有关(P<0.05),其中Ku80与HER-2密切相关(rs=0.319,P=0.010)。结论:Ku80表达水平与影响乳腺癌患者预后的生物学特征相关,特别是与HER-2关系密切;Ku80与HER-2之间可能存在调控通路。

Objective: To study the expression of Ku80 in breastal carcinoma and to explore the correlation between the expression of Ku80 and the characters of clinic, pathology and biology. Methods: Immunohistochemistry was used to measure the expression of Ku80, ER, PR, HER-2 and mutant p53 in 65 cases of breast carcinoma. Results: The expression of Ku80 was 78.5% and was associated with the tumor size and the expressions of ER, PR, HER-2 and mutant p53 (P<0.05). It was positively correlated with HER-2(rs=0.319, P=0.010). Conclusions: The expression of Ku80 in breast carcinoma had close relationship with prognosis factors, especially with HER-2; there may be a modulation pathway between Ku80 and HER-2.