狼疮肾炎危险因素分析

The risk factors for Chinese patients with lupus nephritis

目的探讨狼疮肾炎(LN)病变的危险因素。方法对79例LN患者进行回顾性分析,并与同期住院的91例无肾炎病变的SLE患者作对照。所有实验室检查均采用标准方法。结果LN患者占同期住院患者的40.3%。与无肾炎病变的SLE患者作对照,其发病年龄明显小于对照组(P<0.001),两组性别和病程方面差异无显著性(P>0.05)。实验室指标对比显示,抗dsDNA抗体、抗Sm抗体、抗心磷脂抗体(aCL)和抗中性粒细胞胞质抗体(ANCA)在LN组有较高的阳性率,与对照组相比差异有显著性(P<0.05)。结论发病年龄小,存在抗dsDNA抗体、抗Sm抗体、aCL和ANCA阳性是SLE易并发肾炎的危险因素。

Objective To explore the risk factors for developing lupus nephritis(LN) in patients with systemic lupus erythematosus.Method A retrospective study of 79 patients with LN,and 91 randomly selected patients with SLE without nephritis as controls was designed.Standard methods were used for laboratory testing.Results Patients with LN were significantly younger than the controls in the ages at onset(P<0.001).There were no differences in sex distribution and disease duration between the two groups.The laboratory tests showed that the positive rate of anti-dsDNA,anti-Sm,anti-cardiolipin(aCL) and antineutrophil cytoplasmic autoantibodies(ANCA) were higher in the group with nephritis than in control group (P<0.05).Conclusion Young patients with positive anti-dsDNA,anti-Sm,aCL and ANCA appear to have a higher risk of renal involvement.These patients should be carefully monitored for the development of LN.