木芙蓉叶有效组分对大鼠肾缺血再灌注损伤的保护作用

Effect of Leaves of Hibiscus mutabilis L.on Renal Ischemia Reperfusion Injury of Rat Model

为了探讨木芙蓉叶有效组分 (MFR)对大鼠肾缺血再灌注损伤中的作用 ,采用大鼠肾缺血再灌注模型 ,木芙蓉叶有效组分灌胃给药 ,观察血清尿素氮 (BUN)、肌酐 (Scr)及肾组织病理变化 ,并检测白细胞介素 - 1(IL- 1 )的含量。结果再灌注 2 4 h后 ,治疗组血 BUN及 Scr明显降低 (P <0 .0 5 ) ;治疗组血液 IL- 1含量与非治疗组相比有显著性差异 (P <0 .0 5 ) ;而且治疗组肾组织病理损伤较非治疗组明显减轻。木芙蓉叶有效组分对肾缺血再灌注损伤有保护作用 ,其原因可能与抑制 IL-

To explore the role of effective fraction of Hibiscus mutabilis L (MFR) on renal ischemia reperfusion injury in rat Using a model of renal ischemia reperfusion injury,determined the change of blood urea nitrogen (BUN),serum creatinine(Scr),the pathological change of kidney tissue and the level of interleukin 1(IL 1) after the Hibiscus mutabilis L was administrated Results At 24 h after reperfusion,the BUN and Scr level decreased significantly in MFR group (P<0 05) The level of IL 1 was marked difference between MFR group and blank group (P<0 05) The renal pathological injury of MFR group was mitigated significantly The results suggest that Hibiscus mutabilis L protects kidney from ischemia reperfusion injury,and that this action may underline its inhibitory action on the interleukin 1 releasing