102例术后乳腺癌辅助化疗后贫血相关因素分析

An Analysis of Anaemia Related Factors in 102 Cases with Breast Cancer Receiving Adjuvant Chemotherapy Post-operatively

[目的]探讨乳腺癌术后辅助化疗后贫血发生的相关因素。[方法]回顾性分析102例乳腺癌辅助化疗病人化疗前及每周期化疗后血红蛋白值,按分期分组观察每周期化疗后贫血发生率;按手术方式分组观察每周期化疗后贫血发生率;按化疗前血红蛋白水平分组观察每周期化疗后贫血发生率。[结果]Ⅰ、Ⅱ、Ⅲ期病人,化疗后贫血发生率无显著性差异(P>0.05),乳房切除术的病人,贫血发生率高于乳房保留术的病人(3周期后P<0.05,4周期后P<0.01),化疗前血红蛋白水平低于110g/L的病人,与化疗前血红蛋白水平高于等于110g/L的病人相比,化疗后贫血发生率升高;化疗前血红蛋白水平<120g/L的病人,与化疗前血红蛋白水平高于等于120g/L的病人相比,化疗后贫血发生率升高。[结论]乳腺癌术后接受辅助化疗的病人,贫血发生率与临床分期无关,与手术方式有关。

To explore the anaemia related factors in patients with breast cancer receiving adjuvant chemotherapy post-operatively. The level of haemoglobin (Hb) in 102 cases with breast cancer were retrospectively analyzed before the first cycle and after every cycle of chemotherapy. The patients were stratified by staging, the mode of surgery and the Hb level before chemotherapy. Occurrence of anaemia was compared between them. There were no statistical significance regarding occurrence of anaemia in patients receiving adjuvant chemotherapy among Ⅰ, Ⅱ, Ⅲ stage(P>0.05). Occurrence of anaemia was higher in patients with mastectomy than that with breast conservative surgery (after 3 cycles P<0.05, after 4 cycles P<0.01). Occurrence of anaemia was higher in patients pre-chemotherapy with Hb<110g/L than that with Hb≥110g/L. [Conclusion] Occurrence of anaemia in patients with breast cancer receiving post operative adjuvant chemotherapy is related to the mode of surgery, while not related to clinical stage.