肺癌患者外周血T淋巴细胞亚群变化及其临床意义

Clinical Significance of Changes on T Lymphcyte Phenotype in Peripheral Blood of Patients with Lung Cancer

[目的]检测肺癌患者T淋巴细胞亚群变化。[方法]采用SAP法检测42例肺癌患者及20例正常对照组的外周血T淋巴细胞亚群,并将肺癌中转移组和未转移组分别与正常对照组进行比较。[结果](1)肺癌转移组CD3+、CD4+阳性率低于未转移组(P<0.05),CD4+/CD8+比值比正常组及未转移组低(P<0.05)。(2)未转移组CD8+低于正常组及转移组(P<0.05)。[结论]肺癌患者细胞免疫功能低下,并且细胞免疫功能随病情进展逐步受到抑制。

To detect the changes on T lymphocyte phenotype in peripheral blood of patients with lung cancer. T lymphocyte phenotype in peripheral blood from 42 cases with lung cancer and 20 healthy controls were detected. T lymphocyte phemtype in patients with metastasis and without metastasis was compared with the healthy controls, respectively. CD3+ and CD4+ ratio in the metastasis group was lower than those no metastasis group(P<0.05). CD4+/CD8+ in the metastasis group was lower than those in the healthy control group and in no metastasis healthy and metastasis groups(P<0.05). [Conclusion] The immunity function of the lung cancer is lower, which becomes worse with the advance of disease.