p53基因突变与中心型非小细胞肺癌支气管镜下肿瘤形态的关系

Relationship between overexpression of p53 and bronchoscopic characteristics in central type non-small cell lung cancer

目的 了解p5 3基因突变与原发性中心型非小细胞肺癌支气管镜下肿瘤形态的关系。方法 对 86例中心型非小细胞肺癌手术切除标本用S -P法检测p5 3蛋白表达情况。结果 鳞癌 6 3例、腺癌 11例、腺鳞癌 12例 ,支气管镜下支气管腔内肿瘤周围黏膜无改变者 (Ⅰ型 ) 33例 (38.37% )、肿瘤周围黏膜出现充血、水肿、粗糙等改变者 (Ⅱ型 ) 5 3例 (6 1.6 3% )。支气管镜下Ⅰ型和Ⅱ型病人的p5 3蛋白阳性表达率分别为 2 4 .2 4 %和 6 7.92 % (χ2 =15 .5 3,P<0 .0 1)。结论 p5 3蛋白表达与中心型非小细胞肺癌支气管腔内肿瘤是否累及周围黏膜有关 ,即p5 3蛋白阳性表达者支气管腔内肿瘤多已累及周围黏膜 ,病变相对较晚。

Objective To observe expression of p53 protein and bronchoscopic characteristics in central type non-small cell lung cancer.Methods 86 specimens from patients with central type non-small cell lung cancer were selected and p53 evaluated by immunohisto-chemical method.Results\ 66 males and 20 females with a mean age of 61.3 years.Squamous cell carcinoma 63,adenocarcinoma 11 and adenosquamous carcinoma 12. Under bronchoscopy,Ⅰtype(the polypoid appeared localized and no invasion to the wall of surrounding bronchi) was in 33(38.37%) patients,Ⅱtype(the mucosa invicinity of the tumor was abnormal)in 53(61.63%) patients. Expression of p53 in Ⅰtype andⅡtype patients were found in 24.24%(8/33) and 67.92%(36/53) cases,respectively(χ 2=15.53,P<0.01).Conclusion It has suggested that p53 status be associated with bronchoscopic characteristics in central type non-small cell lung cancer. The majority of expression of p53 is Ⅱtype patients.