卵巢恶性肿瘤组织中C-erbB_2的表达与其临床病理特征的关系

The relationship between the expression of C-erbB_2 and clinicopathological characteristics in ovarian cancer

目的 探讨C erbB2 表达与卵巢恶性肿瘤临床病理及其预后的关系。方法 采用SABC免疫组织化学方法检测4 9例卵巢恶性肿瘤、2 1例良性肿瘤及 1 9例正常卵巢组织中C erbB2 蛋白的表达。结果 (1 )C erbB2 在恶性肿瘤中的表达率为75 5 % ,明显高于良性肿瘤及正常组织 ,差异均有显著性 (P <0 0 5 )。而良性肿瘤与正常组织无明显相关 (P >0 0 5 )。 (2 )C erbB2 在恶性卵巢肿瘤中表达与组织学分级无相关。 (3)C erbB2 在Ⅲ～Ⅳ期的表达率明显高于Ⅰ～Ⅱ期 (P <0 0 1 ) ;腹水≥5 0 0ml的表达率明显高于腹水 <5 0 0ml者 (P <0 0 1 )。 (4 )C erbB2 在淋巴结阳性、大网膜有转移患者中的表达率明显高于阴性者(P <0 0 5 ,P <0 0 1 ) ;术后残留灶 >2cm的表达率明显高于术后无残留灶者 (P <0 0 5 )。 (5 )C erbB2 阳性者的累积生存率明显低于阴性者 (P <0 0 5 )。结论 C erbB2 与卵巢肿瘤的发生、恶化有关 。

Objective To explore the relationship between the expression of C erbB 2 protein and clinicopathological characteristics in ovarian cancer Methods The immunohistochemical SABC method was used to detect C erbB 2 protein expression in 49 ovarian cancers,21 benign tumors and 19 normal controls Kaplan Meier Method and Coxs proportional hazard regression model were used to analyze the relationship of their expressions with prognosis Results (1)Positive expression rate of C erbB 2 protein in ovarian cancer was 75 5%,significantly higher than that in benign tumors and in normal controls(P<0 01);no significant correlation was observed between benign tumors and normal control (2) No significant correlation was observed between positive rate of C erbB 2 protein and pathological type or grade in ovarian cancer (3)Positive expression rate of C erbB 2 protein in stage Ⅲ～IV of patient was much higher than that in stageⅠ～Ⅱ of patient(P<0 01),and positive rate of C erbB 2 in patient with amount of ascites volume≥500ml was much higher than that with ascites volume <500ml(P<0 01) (4)Positive expression rate of C erbB 2 protein in that patients with lymph node metastasis or omentum involvement was significantly higher than without metastasis,and positive expression in patients with tumor residue≥2cm was higher than that in those with none(P<0 05) (5)The cumulate survival rate in patients with positive expression rate of C erbB 2 was lower than that in patients with negative expression(P<0 05) Conclusion:The expression of C erbB 2 protein is correlated with the carcinogenesis and progress of ovarian cancer,and can be regarded as a biomarker for predicting prognosis