胎儿染色体异常的孕中期联合筛查

Pregnancy medium-term united screening on fetal abnormal chromosome

目的 :应用产前联合筛查 ,筛查胎儿染色体异常的可行性。方法 :对 2 5 90名孕妇的年龄及病史、血清学、超声的联合筛查 ,并行产前诊断及染色体核型分析。结果 :染色体异常 7例 ,检出率 7.2 2 % (7/97) ,以染色三体为主 4例 ,占 5 7.14 % (4 /7)。结论 :通过联合筛查及产前诊断可检出胎儿染色体异常 ,选择性终止妊娠 ,减少出生缺陷。但联合筛查的指标还需完善。

Objective:To investigate the feasibility of examining fetal abnormal chromosome by antenatal united sureening.Methods:2 590 pregnant women are examined about their age,medical records,serology and ultrasound,at the same time prenatal diagnosis and chromosomal karyotype's analysis were conducted.Results:There are 7 cases of karyotypes abnormal(7.22%,9/97) and 4 cases of trisomy (57.14%,4/7).Conclusion:It is feasible to screen fetal chromosomal abnormity to selectively terminate pregnancy and decrease natal disfigurement by united sureening and prenatal diagnosis.But the guideline of associated examination still need to be perfected constantly.