小儿支原体感染与自身免疫关系探讨

Relationship between children with mycoplasma infection and their autoimmunity

目的 :通过观察支原体感染小儿体内自身抗体的变化 ,探讨支原体感染与自身免疫的关系。方法 :对 5 4例呼吸道感染伴持续发热、频咳的小儿分别用金标免疫斑点法检测支原体抗体 (Ig M,Ig G) ,用抗核抗体 (DNA)检测卡测抗核抗体、抗双链DNA抗体、类风湿因子等 ,并将 5 4例患儿分成两组 ,其中以支原体抗体阳性组为 A组 ,支原体抗体阴性组为 B组。对其临床特征进行分析。结果 :支原体抗体阳性者 2 2例 (A组 ) ,支原体抗体阴性者 32例 (B组 ) ,其中 A组有 10例 ,B组有 4例抗核抗体、抗双链DNA抗体及类风湿因子阳性。两组自身抗体异常率比较 ,A组明显高于 B组。经卡方检验χ2 =3.34,P<0 .0 5。结论 :肺炎支原体感染时 ,体内可发生自身免疫性反应 ,抗核抗体阳性率较高 ,且以年长儿多见。

Objective:To explore the relationship between mycoplasma infection and autoimmunity by observing the changes of internal autoantibodies of children with mycoplasma infection. Methods:54 children patients with respiratory tract infection complicating durative fever and frequent cough were examined. Mycoplasma antibodies (IgM, IgG) were determined using golden immune blotting method; antinuclear antibody (ANA), anti-double chains DNA antibody and rheumatoid factor were determined by ANA detective card. All children patients were divided into the positive mycoplasma antibodies group (group A) and the negative mycoplasma antibodies group (group B). Then the clinical characteristics were analyzed. Results: Of 22 cases with positive mycoplasma antibodies (group A) and 32 cases with negative mycoplasma antibodies (group B), ANA, anti-double chains DNA antibody and rheumatoid factor of 10 cases in group A and 4 ones in group B were positive. The abnormal rate of autoantibodies in the group A was significant higher than that in the group B (χ2=3.34,P<0.05). Conclusion: The children with pneumonia mycoplasma infection could have autoimmunity reaction and higher positive rate of ANA, and that is common in older children.