利多卡因对充血性心力衰竭患者某些细胞因子的变化及影响

Effects of lidocaine on the change of some cytokines in patients with congestive heart failure

目的 探讨利多卡因对充血性心力衰竭 (CHF)患者单核细胞 (PBMC)分泌肿瘤坏死因子 α(TNF α)、白细胞介素 1β (IL 1β)和IL 6的影响。 方法 测定正常人和CHF患者血清中各细胞因子含量 ,以及加入不同浓度利多卡因前后 ,PBMC分泌各细胞因子的变化。结果 CHF患者血清各因子均明显高于对照组 (P <0 0 0 1)。利多卡因可刺激各细胞因子的分泌 (P <0 0 0 1)。结论 细胞因子TNF α、IL 1β和IL 6可能参与CHF的发生 ;利多卡因刺激细胞因子的分泌 。

Objective To examine the effect of lidocaine on the prodution of tumor necrosis-α(TNF-α),interleuking-1β(IL-1β)and IL-6 in patients with congestive heart failure(CHF).Methods Serum cytokines contents in healthy volunteers,serving as normal control group(n=20)and CHF patients(n=20)were measured by an Enzyme-linked immunosorbent assay(ELISA). All the cytokines in culture supernatants were also measured before and after lidocaine was added.Results Serum cytokines contents in CHF group were significantly higher than in the control group(P<0. 001). The production of the cytokines were greatly stimulated by lidocaine in both groups in a concentration-depended manner.Conclusion TNF-α, IL-1β and IL-6, may play an important role in the pathogenesis of CHF; lidocaine may damage heart function by stimulation of the production of some certain cytokines.