摘要
铁螯合剂可显著影响细胞内外铁的水平。对铁螯合剂的研究主要集中在治疗地中海贫血患者因长期输血引起的慢性铁超载。此外,螯合剂还有抗氧化应激损伤、抗肿瘤细胞增殖和细胞毒、诱导细胞凋亡以及其它有趣的药物学特性。本文就这些方面的研究及进展作一综述。
出处
《国外医学（输血及血液学分册）》
2004年第3期247-249,共3页
Foreign Medical Sciences(Section of Blood Transfusion and Heanatology)
参考文献26
-
1Chaston TB,Lovejoy DB,Watts RN,et al.Examination of the antiproliferative activity of iron chelators: multiple cellular targets and the different mechanism of action of triapine compared with desferrioxamine and the potent pyridoxal isonicotinoyl hydrazon
-
2Galanello R, Piga A, Alberti D,et al. Safety, tolerability, and pharmacokinetics of ICL670, a new orally active iron- chelating agent in patients with transfusion-dependent iron overload due to beta-thalassemia J Clin Pharmacol,2003,43(6): 565-572.
-
3Rouan MC, Marfil F, Mangoni P,et al. Determination of a new oral iron chelator, ICL670, and its iron complex in plasma by high-performance liquid chromatography and ultraviolet detection.J Chromatogr B Biomed Sci Appl,2001,755(1-2):203-213.
-
4Horackova M, Ponka P, Byczko Z. The antioxidant effects of a novel iron chelator salicylaldehyde isonicotinoyl hydrazone in the prevention of H2O2 injury in adult cardiomyocytes. Cardiovasc Res,2000,47(3):529-536.
-
5Grunblatt E, Mandel S, Maor G,et al.Gene expression analysis in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice model of Parkinson's disease using cDNA microarray:effect of R-apomorphine. J Neurochem,2001,78:1-12.
-
6Gao J, and Richardson DR. The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents, Ⅳ: The mechanisms involved in inhibiting cell-cycle progression.Blood,2001,98(3):842-850.
-
7Galanello R. Iron chelation: new therapies.Semin Hematol,2001,38(1 Suppl 1):73-76.
-
8Martelius T,Scholz M,Krogerus L,et al. Antiviral and immunomodulatory effects of desferrioxamine in cytomegalovirus-infected rat liver allografts with rejection.Transplantation,1999,68(11):1753-1761.
-
9Tetef ML,Synold TW,Chow W, et al. Phase I trial of 96-hour continuous infusion of dexrazoxane in patients with advanced malignancies.Clin Cancer Res,2001,7(6):1569-1576.
-
10Becker EM, Lovejoy DB, Greer JM, et al. Identification of the di-pyridyl ketone isonicotinoyl hydrazone (PKIH) analogues as potent iron chelators and anti-tumour agents. Br J Pharmacol,2003,138(5): 819-830.
同被引文献22
-
1Horwitz L. D, Rosenthal EA. Iron - mediated cardiovascular injury. Vasc Med,1999, 4(2) :93.
-
2Failla M, Gannattasio C, Piperno A, et al. Radial artery wall alterations in genetic hemochromatosis before and after iron depletion therapy. Hepatology ,2000,32 (3): 569.
-
3Lee T, Shiao M,Pan C,et al. Iron - deficient diet reduces atherosclerotic lesions in ApoE - deficient mice. Circulation, 1999,99:1222.
-
4Sullivan JL. Iron and the sex difference in heart disease risk. Lancet,1981 ,1 (8233) :1293.
-
5Valk B, Marx J. Iron,atherosclerosis,and ischemic heart disease.Ach Intern Med, 1999,159(14) :1542.
-
6Bartfay WY, Bartfay E. Iron - overload cardiomyopathy: evidence for a free radia l2 mediated mechanism of injury and dysfunction in a murine model. Biol Res Nurs , 2000,2(1) :49.
-
7Brasen JH,Kivela A,Roser K,et al. Angiogenesis,vascular endothelial growth factor and platelet - derived growth factor expression,iron deposition, and oxidation -specific epitopes in stented human coronary arteries. Arterioscler Thromb Vase Biel,2001,21(11) :1720.
-
8Araujo JA, Romano EL, Brito BE, et al. Iron overload augments the development of atherosclerotic lesions in rabbits. Arterioscler Thromb Vasc Biol ,1995 ,15(8) :1172.
-
9Ren Minqina, Reshmi Rajendrana. The iron chelator desferrioxamine inhibits atherosclerotic lesion development and dccreases lesion iron concentrations in the cholesterol - fed rabbit. Free Radical Biology & Medicine ,2005,38:1206.
-
10We Jian Zhang,Balz Frei. Intracellular metal ion chelatorors inhibit TNF - induced SP - 1 activation and adhention molecule expression in human aortic endothelia cells. Free Radical Biology &Medicine, 2003,34 (6): 674.
二级引证文献2
-
1孙明霞,华颖,王健彪,周逸能,周坚.IBA57基因突变致常染色体隐性痉挛性截瘫一家系临床分析[J].中华神经科杂志,2023,56(8):902-908.
-
2潘婷婷,伍三霞,张钦.Habilitation护理模式对智能减退患者认知功能、自理能力及生活质量的影响[J].齐鲁护理杂志,2023,29(19):9-12.
-
1王令,耿国平,李青.胰岛素泵释药系统的研究及进展[J].国际医药卫生导报,2008,14(20):109-112.
-
2刘孝霞,郭旭玲,刘希君.哌拉西林的应用研究及进展[J].齐鲁药事,2005,24(6):360-362. 被引量：4
-
3橄榄油的药效[J].求医问药,2006,0(1):51-51.
-
4袁洁,李娟,曲维忠,楚立,张颖.丹参注射剂对铁超载斑马鱼的保护作用[J].内蒙古中医药,2014,33(8):42-43.
-
5葛涛,梁国栋.蚓激酶研究进展[J].中国生物工程杂志,2003,23(4):48-52. 被引量：14
-
6吴同果.重组人脑钠肽在急性心力衰竭治疗中的研究及进展[J].岭南心血管病杂志,2010,16(6):441-443. 被引量：4
-
7罗格莲.眼镜蛇毒细胞毒素抗肿瘤作用的研究及进展[J].海峡药学,2007,19(11):4-7. 被引量：1
-
8张建英,杨平,李益强,祁丕东.他汀类药物除调脂作用外的临床有益作用[J].中国药业,2006,15(2):80-80. 被引量：9
-
9邬占慧.抗菌药物临床应用、不良反应及预防[J].中国医药指南,2011,9(16):209-210.
-
10张爱君,宣昭林.砷诱导细胞凋亡机制[J].中国地方病防治,2005,20(4):218-222. 被引量：5
