两种不同结构类型的钾通道开放剂埃他卡林和吡那地尔联合用药降压作用的特征

Antihypertensive characteristics of combination of iptakalim and pinacidil,potassium channel openers

目的 :观察两种不同种类的钾通道开放剂(potassiumchannelopeners ,KCOs)埃他卡林 (iptakal im ,Ipt)和吡那地尔 (pinacidil ,Pin)联用降压作用的特征。方法 :用无创性套尾法观察药物对清醒大鼠血压和心率的影响。结果 :Pin在 2 .0和 4 .0mg·kg-1剂量下 ,可剂量依赖性降低清醒大鼠的血压 ,加快其心率。Ipt在 2 .0 ,4 .0和 8.0mg·kg-1剂量下 ,可剂量依赖性降低血压 ,但不影响心率。Ipt(2 .0～8.0mg·kg-1)与Pin(4 .0mg·kg-1)合用时 ,其降压作用产生协同效应 ,但加快心率的作用与Pin相同。结论 :Ipt和Pin降压特点不同 ,二者联用的降压作用增强。

AIM: To study the antihypertensive characteristics of iptakalim (Ipt) and pinacidil (Pin), the potassium channel openers (KCOs) of aliphatic amines and guanidine monohydrate, respectively. METHODS: The conscious noninvasive method with tail cuff was performed in rats to record the systolic blood pressure (SBP) and HR. RESULTS: SBP decreased and HR increased prominently in a dose dependent manner after treatment with Pin at the doses of 2.0 and 4.0 mg·kg -1 . While treated with Ipt at the doses of 2.0 , 4.0 and 8.0 mg·kg -1 under the same experimental conditions, SBP decreased but HR had no significant change. When administered with Ipt and Pin simultaneously, SBP decreased synergistically, and the effects on elevating HR were equal to that of Pin. CONCLUSION: Antihypertensive characteristics of Ipt are different from that of Pin, and the antihypertensive effects can be strengthened by combination of Pin and Ipt.