针刺颅骨缝加药物治疗急性脑梗死患者的临床研究

Clinical study on needling skull suture plus medicine for treatment of acute cerebral infarction

目的 :探讨提高治疗急性脑梗死 (CI)疗效的最佳方法。方法 :6 0例早期CI患者 ,随机分为A、B两组 ,B组采用CI早期常规药物治法 ,A组在B组治疗基础上加用颅针治疗。结果 :A组治疗后神经功能较治疗前差异有非常显著性意义 (P <0 0 1) ,血小板膜糖蛋白 (GMP 14 0 )较B组下降有显著性意义 (P <0 0 5 )。结论 :①颅针加药物改善临床神经功能 ,抑制血小板活化优于单纯药物治疗组。②CI早期 ,治疗前后神经功能缺损评分值与血浆GMP 14 0水平呈中度正相关 ,表明血浆GMP 14 0水平可作为CI患者病情轻重和预后的客观指标。

Objective To approach to the best method for treatment of acute cerebral infarction (CI). Methods Sixty cases of early CI were randomly divided into a group A and a group B. The group A were treated by routine medication for early CI and the group B were treated by the medication plus skull needling. Results There was a very significant difference before and after treatment in the nervous function in the group A (P<0 01) and the granular membrane glycoprotein in platelet (GMP-140) decreased significantly as compared with that in the group B(P<0 05). Conclusion Skull needling plus medication improves the clinical nervous function and it is superior to the group B in inhibiting activation of platelet; at early stage of CI, before and after treatment the neurological deficit score and the plasma GMP-140 level show a moderate correlativity, indicating GMP-140 level can used as an objective index of state of illness and prognosis for the patient of CI.