血清乙型肝炎核心抗原(HBcAg)的研究

A STUDY ON SERUM HEPATITIS B CORE ANTIGEN

用 RIA 法检测了676份血清的 HBcAg,探讨了 HBcAg 与 HBV 五项血清学标志(HBsAg、抗-HBs、HBeAg、抗-HBe 和抗-HBc),抗-HBcIgM及各型乙型肝炎的关系。结果表明:在 HBV 五项血清学标志的各种模式中,第1模式(HBsAg、HBeAg 和抗-HBc 阳性)和第2模式(HBsAg、抗-HBe和抗-HBc 阳性)的 HBcAg 检出率最高,分别为91.1％和86.5％,两者无显著差异(P>0.05),提示在 HBsAg、抗-HBc 阳性情况下,e 系统转化时,血清传染性无明显改变;HBcAg 与抗-HBcIgM 有密切的关系,提示后者也是反映 HBV复制的指标;HBcAg 在4例重症肝炎全部阳性,慢性活动性肝炎中94.7％阳性,看来 HBV 的持续存在与病变活动程度有关。

In order to study the relation of HBcAg in serum with five HBV serologic markers (HBsAg,Anti-HBs,HBeAg,Anti-HBe and Anti-HBc),Anti-HBcIgM and various types of hepatitis B,We tested 676 sera for HBcAg with RIA. The result revealed that in 21 models of HBV serologic markers,model 1 (HBsAg,HBeAg and Anti-HBc positive) and model 2 (HBsAg,Anti-HBe and Anti-HBc positive) had higher percentages of HBcAg (91.1% and 86.5%). There was no statistical difference between them (P>0.05).So it was suggested that when HBsAg and Anti-HBc exist,the conversion of E system can not chang the infectivity of serum.There was a good relationship between HBcAg and Anti-HBcIgM,Thus it was likely that Anti-HBcIgM was a marker of HBV replication.Our study also showed that persistent existence of HBV in serum was closely related to the degree of liver disease activity.