急性肺栓塞溶栓治疗的循证医学

The Evidence-Based Medicine of Trombolytic Therapy for Acute Pulmonary Embolism

肺栓塞是一种具有较高的发病率和病死率的常见病。尽管抗凝治疗已经被公认为肺栓塞的标准治疗 ,但由于溶栓治疗能够快速溶解血栓 ,故被认为是一种更理想的治疗选择。 3 0年来很多试验对此作了针对性的研究 ,但结果存在争议 ,在这篇文章里 ,笔者主要对期间的多中心的临床试验作一回顾和总结。

Pulmonary embolism(PE) is a common disease with significant morbidity and mortality.Alough anticoagulation is the standard treatment for PE,thrombolytic therapy,with the ability to produce rapid clot lysis,has been considered as a more ideal choice.In the past three decades many studies have focused on this topic,but the result is remaining controversial.In this article those muticenter clinical trials are reviewed and dicussed.