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细胞凋亡信号传导途径的研究进展 被引量：16

Progress study on signal transmission of apoptosis
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摘要 细胞凋亡是细胞主动死亡过程 ,在细胞的发育和疾病的发生中起重要作用。对于细胞凋亡信号传导途径的研究 ,近年来一直是生命科学领域的研究热点 ,已经取得了突破性进展 ,目前认为电离辐射等因素通过 DNA损伤而诱发细胞凋亡可能主要存在 3条信号传导途径 ,即细胞凋亡的死亡受体途径 ,线粒体途径和 p5 3基因依赖的调控途径。
作者 刘光伟 龚守良
机构地区 吉林大学公共卫生学院卫生部放射生物学重点实验室
出处 《吉林大学学报（医学版）》 CAS CSCD 北大核心 2004年第3期485-488,共4页 Journal of Jilin University：Medicine Edition
基金 国家教委基金资助课题 (1 996 )
关键词 细胞凋亡 信号传导 基因表达调控 DNA损伤
分类号 Q25 [生物学—细胞生物学]
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参考文献30

  • 1Krueger A, Baumann S, Krammer PH. FLICE inhibitory proteins: regulators of death receptor mediated apoptosis [J]. Mol Cell Biol, 2001, 21 (24): 8247-8254.
  • 2Stewart JH, Nguyen D, Chen GA, et al. Induction of apoptosis in malignant pleural mesothelioma cells by activation of the Fas (Apo-1/CD95) death signal pathway [J]. J Thorac Cardiovasc Surg, 2002, 123 (2): 295-302.
  • 3Ledgerwood EC, Pober JG, Bradley JR, et al. Recent advances in the molecular basis of TNF signal transduction [J]. Lab Invest, 1999, 79 (13): 1041-1050
  • 4Oliveira PL, Garcia S, Lecoeur H, et al. Increased sensitivity of T lymphocytes to tumor necrosis factor receptor (TNFR1)and TNFR2 mediated apoptosis in HIV injection: relation to expression of Bcl-2 and active caspase 8 and caspase 3 [J].Blood, 2002, 99
  • 5Park KJ, Chai SH, Kim DJ, et al. Hepatitis C virus core protein potentiates c-Jun N-terminal kinase activation through a signaling complex involing TRADD and TRAF2 [J]. Virology,2001, 74 (1-2): 89-98.
  • 6Gupta S. Molecular steps of tumor necrosis factor receptor mediated apoptosis [J]. Curr Mol Med, 2001, 1 (3): 317-324.
  • 7Sartorius U, Schmitz I, Krammer PH, et al. Molecular mechanisms of death receptor mediated apoptosis [J]. Biochem,2001, 2 (1): 20-29.
  • 8Snearwin WL, Harvey NL, Kumar S. Subcelular localization and CARD dependent oligomerization of the death adaptor RAIDD [J]. Cell Death Differ, 2000, 7 (21): 155-165.
  • 9Yeh WC, Dompa JL, Mccarrach ME, et al. FADD: essential for embryo development and signaling from some, but not all,inducer of apoptosis [J]. Science, 1998, 279 (5): 1954-1958.
  • 10Kuang AA, Diehl GE, Zhang J, et al. FADD is required for DR4- and DR5-mediated apoptosis: lack of trail induced apoptosis in FADD deficied mouse embryonic fibroblasts [J].Biochem Biophys Res Commun, 2000, 60 (1): 4119-4147.

二级参考文献19

  • 1Wang QF, Chen JC, Hsieh SJ, et al. Regulation of Bcl-2 family molecules and activation of caspase cascade involved in gypenosides induced apoptosis in human pipatoma cells[J]. Cancer Lett, 2002, 183(2):169-178.
  • 2Nakagami H, Morishi R, Yamamoto K, et al. Hepatocyte growth factor prevents endothelial cell death through inhibiton of Bax translocation from cytosol to mitochondrial membrane[J]. Diabetes, 2002, 51 (8): 2604-2611.
  • 3Yamamura T, Otani H, Nakao Y, et al. IGF-I differentially regulates Bcl-xl and Bax and confers myocardial protectionin the rat heart[J]. Am J Physiol Heart Circ Physiol, 2001,80(3): 1191-1200.
  • 4Dimatola T, Dascoli F, Fenzi G, et al. Amiodarone induces cytochrome c release and apoptosis through an iodine independent mechanism[J]. J Clin Endocrinol Metab, 2000,85(11): 4323--4330.
  • 5Sugiyema T, Shimizu S, Matsuoko Y, et al. Activation of mitochondrial voltage dependent anion channel by aproapoptotic BH3-only protein Bim[J]. Oncogene, 2002, 21(32): 4944--4956.
  • 6Mather M, Rottenberg H. Polycations induce the release of soluble intermembrane mitochondrial proteins[J]. Biochem Biophys Acta, 2001, 1503(3): 357-368.
  • 7Lam M, Oleinick NL, Nieminen AL. Photodynamic therapy induced apoptosis in epidermoid carcinoma cells, reactive oxygen species and mitochondrial inner membrane permeabilization[J]. J Biol Chem, 2001, 276(50): 47379--47386.
  • 8Kleibl Z, Raisova M, Novotny J, et al. Apoptosis and its importance in the development and therapy of tumors[J]. SB Lek, 2002, 103(1): 1-13.
  • 9Eskes R, Rosse T. Bax-indueed cytoehrome c release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2^+ ions[J]. J Cell Biol, 2000,143(2): 217-224.
  • 10Basanez G, Zhang J, Chau BN, et al. Pro-apoptotic cleavage products of Bcl-xl from cytochrome c conducting pores in pure lipid membranes [J]. J Biol Chem, 2001, 276 (33):31083-31097.

共引文献14

同被引文献138

引证文献16

二级引证文献33

吉林大学学报（医学版）
2004年 第3期

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