米索前列醇防治高危产后出血临床研究

The Efficacy of Misoprostol in the Prevention of Postpartum Hemorrhage in the Parturient with High Risk Factor

目的 :观察口服米索前列醇用于预防高危产后出血的效果。方法 :将足月妊娠分娩有发生产后出血高危因素的产妇 98例随机分为 :①实验组 :5 0例 ,在胎儿娩出后立即口服米索前列醇 4 0 0 μg ,②对照组 :4 8例 ,在胎儿娩出后立即宫体内注射催产素 2 0U。产后 2 4h内平均出血量 ,试验组 (390± 6 2 .9)mL ,对照组 (435± 6 9.3)mL ,两组比较 ,P <0 .0 5。用药前后血压变化差异无显著意义。结论 :米索前列醇具有比催产素更强的子宫收缩作用 ,能很好地预防高危因素的产后出血 ,且用药方便、安全。

Objective: To determine the efficacy of misoprostol in the prevention of postpartum hemorrhage in the parturient with high risk. Method: 98 cases of term delivery were observed. the 98 parturients with high risk of postpartum hemorrhage were randomly divided into the study group (n=50) and the control group (n=48). In the study group, misoprostol 400 μg was taken orally as soon as the labor was over while in the control group, oxytocin 20U was injected in uterine muscle instead. Then the hemorrhage was compared between the two groups. Results: The amount of postpartum hemorrhage was (390± 62.9)ml in the study group which was significantly lower than that of the control group (435± 63.3)ml, P< 0.01. And the blood pressure taken after the drug didn't have any statistically significant difference than before in both of the two groups.Conclusion: Misprostol has a stronger efficacy on uterine contraction ,and has a safe prevention of postpartum hemorrhage in the parturient with high risk factor.