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用于组织工程中的多(醚-脂)阻断共聚物的细胞相容性 被引量:1

Cytocompatibility of poly (ether-esters) block- copolymers for use in tissue engineering
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摘要 poly(ethyleneglycol)/poly(butylenesterephthalate)(PEG/PBT)已经在最近作为生物可降解材料应用于组织工程之中[1,2,3].现在,在PEG/PBT的基础上合成了两种新型材料,它们是:poly(butylen esterephthalate co 1,4 cyclohexenedimethylenetere phthalate b ethyleneglycolterephthaloyl)(PTCG),和poly(butylenesterephthalate) co poly(butylenessuccinate) b poly(ethyleneglycol)(PTSG).它们具有两种硬片段,这使它们能够比PEG/PBT更好地调整材料的组分以使得它们能够具有更合适的可降解速度和更好的力学性质.还可以使它们能够减少硬片段的容量和长度,同时还不牺牲材料的力学性质,使材料对于人体更为安全.所以,如果这两种材料的生物相容性一律良好,它们将会比PEG/PBT在组织工程中有更好的应用前景.
出处 《大连大学学报》 2004年第2期17-19,共3页 Journal of Dalian University
基金 the National Hi-Tech"863"Plan Fund(2001AA216077) "Tissue Engineering"special item from Beijing Science and Technology Committee(H020920040330).
关键词 组织工程 多(醚-脂)阻断共聚物 细胞相容性 生物材料 可降解材料 PEG/PBT biodegradable material PEG/PBT tissue engineering
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参考文献3

  • 1[1]Beumer GJ, van Blitterswijk CA, Bakker D, Ponec M. Biomaterials. 1993 Jul;14(8): 598-604.
  • 2[2]Liu Q, de Wijn JR, van Blitterswijk CA. J Biomed Mater Res. 1998 Jun 5;40(3):490-7.
  • 3[3]Olde Riekerink MB, Claase MB, Engbers GH, Grijpma DW, Feijen J. J Biomed Mater Res. 2003 Jun 15;65A(4):417-28.

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  • 1张勇,冯庆玲,崔福斋,冯增国.不同软段长度PBT-co-PCT-b-PEG嵌段共聚物的结构与性能[J].高分子材料科学与工程,2005,21(1):180-183. 被引量:4
  • 2C.M.Patist,M.B.Mulder,S.E.Gautier,Freeze-dried poly(d,l-lactic acid) macroporous guidance scaffolds impregnated with brain-derived neurotrophic factor in the transected adult rat thoracic spinal cord,Biomaterials,25,1569(2004)
  • 3C.Schugens,V.Maquet,C.Grandfils,Biodegradable and macroporous polylactide implants for cell transplantation:1.Preparation of macroporous polylactide supports by solid-liquid phase separation,Polymer,37(6),1027(1996)
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  • 7Tanaka Takaaki,Lloyd Douglas R.,Formation of poly(l-lactic acid) microfiltration membranes via thermally induced phase separation.Journal of Membrane Science,238(1~2),65(2004)
  • 8Rong Zhang,Wenjian Weng,Piyi Du,Gaoling Zhao,Ge Shen,Gaorong Han,Effect of pluronic F127 on the pore structure of macrocellular biodegradable polylactide foams,Polymers for Advanced Technologies,15(17),425(2004)
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