营养基因组学研究与应用

The Study and Application of Nutrigenomics

营养基因组学是高通量基因组技术在日粮营养素与基因组互作及其与健康关系研究中的应用.随着人类和模式动物基因组的阐明以及近年有关技术的进展,同时进行生物样品中DNA,mRNA和表达的蛋白质分析,确定基因的多样性已成为可能.它将加速认识营养如何影响代谢途径和机体稳态控制,发现与营养有关疾病早期调节失控与基因型的关系.应用营养基因组学建立评价营养素利用效率的标识和方法,可为公众健康提供有效的科学依据.利用营养基因组学技术能够提高产品质量与生产效率,促进食品工业发展和开拓新的市场.

Nutrigenomics is the application of high-throughput genomics technology in nutrition research. In keeping with the unraveling of the human genome and model animal's genome, recent technological advancements have made it possible to analyze simultaneously numerous sets of DNA, mRNA and/or proteins expressed in a biological sample or to define genetic polymorphism. It may be important for research of the individual response of an organism to its nutritional environment changes. It will promote an increased understanding of how nutrition influences metabolic pathways and homeostatic control; how this regulation is disturbed in the early phase of a nutrient-related disease and to what extent each individual sensitizing genotypes contribute to such diseases. Ultimately, nutrigenomics are providing the necessary understanding to develop and evaluate different approaches to manipulate bioactive compounds, new biomarkers for the in vivo efficacy of nutrients. Nutrigenomics will allow effective dietary-intervention strategies to recover normal homeostasis and to prevent diet-related diseases.