隐翅虫体内毒素与皮炎关系的实验观察

AN EXPERIMENTAL OBSERVATION ON THE TOXIN OF PAEDERUS FUSCIPES AND ITS CAUSATIVE DERMATITIS

20 0 0年 6月在合肥市郊发生了隐翅虫皮炎流行。为了阐明隐翅虫体内毒素与皮炎等疾病的关系 ,将头、胸、腹 ,分别放在志愿者皮肤上夹碎 ,观察反应。涂抹后 6h皮肤红肿 ,其后炎症反应渐加重。第 3～12天发展成硬块、水疱、脓疱、坏死、结痂 ,并伴有疼痛等症状和体征 ;第 13天炎症渐消退 ;第 19天痂皮脱落 ,但留下疤痕可持续 9个月。虫体经 4℃冷存 6h后 ,其毒性破坏 ,不能引起皮炎反应。虫体用 70 %酒精重量 (1∶10 0 )浸泡 ,6个月后分别配制 1 0 %和 0 5 %的浸液 ,对实验动物的皮肤、眼部进行实验 ,结果表明炎症反应随浸液浓度的增高而加重。

The outbreak of epidemic Paederus dermatitis occurred among students of the university at the suburb of Hefei in June 2000. To clarify the relationship between the toxin of Paederus fuscipes and dermatitis, the beetles were captured and dissected into head,thorax, and abdomen. The dissections were grinded separatively on the skin of front arm of volunteers. The red swelling of the skin was noted after 6 hours of the spreading and the inflammation became progressive and blister, pustule, necrosis, and scab with sudden onset of a stinging emerged on day 12. The dermatitis extincted gradually after that. The crust exfoliation occurred on day 19 and the scar remained as long as nine months. The toxic effect of the beetle on the skin observed above could be inhibited by the beetle stored at 4℃ for 6 hours before spreading. The severe dermatitis and inflammation of eyes could be caused in animals by the beetle soaked in 70% alcohol for six months. Pathological changes were observed in dermal layer and subcutaneous connective tissue of the experimental rabbits.