原发性高血压患者瘦素及神经肽Y与血脂的关系

Relationship Among Leptin, Neuropeptide Y and Plasma Lipid in the Patients with Essential Hypertension

目的 研究原发性高血压患者瘦素及神经肽Y与血脂的相互关系。方法 对 116例原发性高血压患者及 2 6例健康对照者采用放免分析法测量瘦素 (LE)及神经肽Y(NPY)浓度 ,并同时测定血总胆固醇 (CH)、甘油三脂 (TG)及高密度脂蛋白胆固醇(HDL)浓度。结果 高血压组体重指数 (BMI)、血CH、TG、NPY及LEP浓度均显著高于正常对照组 ,而HDL浓度则显著低于正常对照组 (P均 <0 0 1)。相关分析显示 ,LE浓度与收缩压、舒张压、BMI、血CH、TG及NPY浓度呈显著正相关 (P均 <0 0 5 )。结论 血浆瘦素浓度升高可能是原发性高血压发病患机制之一 。

Objective To study the relationship among leptin, neuropeptide Y and plasma lipid in the patients with essential hypertension. Methods In 116 patients with essential hypertension (EH) and 26 healthy subjects, the plasma concentrations of leptin(LE), neuropeptide Y(NPY), total cholesterol(TC), triglyceride(TG) and high density lipoprotein cholesterol(HDL) were determined using RIA. Results The body mass index (BMI), plasma concentrations of TC, TG, NPY and LE were higher in the patients with EH than those in healthy subjects, and the HDL concentration was lower than that in control group (P<0 01). Correlation analysis showed that the LE concentration was positive correlation with systolic blood pressure, diastolic blood pressure, BMI, and the plasma levels of TC, TG and NPY(P<0 05). Conclusion The increase of plasma leptin may be one of the causes of developing high blood pressure, and it may be related to the disorder of plasma lipid and obesity by the role of neuropeptide Y in patients with essential hypertension.