nm23基因与三氧化二砷抗胃癌作用关系的研究

Study on Relationship between nm23 Gene and the Inhibition Effect of Arsenic Trioxide on Human Gastric Carcinoma

目的 探讨三氧化二砷 (As2 O3 )抗肿瘤作用与nm2 3的关系。方法 As2 O3 作用于体外培养的人胃癌细胞株 ,应用免疫组化技术检测nm2 3基因编码蛋白。结果 经As2 O3 作用的人胃癌细胞nm2 3基因编码蛋白表达增加。结论 As2 O3 的抗肿瘤作用可能与上调nm2 3基因编码蛋白表达 ,从而抑制了肿瘤转移有关。

Objective To explore the relationship between the inhibiting effect of arsenic trioxide(As 2O 3) on tumor and nm23 gene expression. Methods The human gastric carcinoma cell line was treated with As 2O 3. Then immunohistochemistry was used to detect nm23 protein expression. Results As 2O 3 up-regulated the expression of nm23 in gastric carcinoma cells. Conclusion The inhibiting effect of As 2O 3 on gastric carcinoma cells may be related with upregulation of nm23 expression, which decreases the gastric cancer cells metastatic ability.