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HIV-1 gp120对鼠海马长时程增强效应的影响 被引量：2

Effect of Long-term Potentiation by HIV-1 gp120 in Rat Hippocampus in vitro
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摘要 为了探讨人类免疫缺陷病毒Ⅰ型 (HIV 1 )的包膜糖蛋白 gp1 2 0对鼠海马脑片CA1 区的突触传递及可塑性的影响 ,应用离体脑片记录技术 ,记录大鼠海马CA1 区的兴奋性突触后电位 (excitatorypostsynapticpotential,EPSP) ,研究了 gp1 2 0对高频电刺激Schaffer侧支引起的鼠长时程增强效应 (long term potentiation ,LTP)的影响。结果发现 :gp1 2 0对大鼠海马CA1 区LTP产生抑制作用 ,对其基础EPSP没有影响 ,而且这种抑制效应随着gp1 2 0浓度增大而增强 ,即具有剂量依赖性。PKA/PKC蛋白激酶抑制剂H7可以反转这种抑制效应。提示 :gp1 2 0可能是通过抑制海马CA1 区的LTP而参与艾滋病相关性痴呆 (HIV 1associateddementia ,HAD) To understand the effect of gp120 on synaptic transmission and plasticity in the CA 1 region of rat hippocampal slices,we recorded the excitatory postsynaptic potentials (EPSPs) and investigated effect of long term potentiation by gp120 in rat hippocampus in vitro.The results showed that HIV 1 gp120 could inhibit the LTP of CA 1,but it could not inhibit the EPSP of basal.The greater the gp120 concentration was, the stronger the inhibitory effect exerted.Protein kinase A and C inhibitors and the H7 could reverse the inhibition effect.Taken together,this inhibition of LTP by gp120 may contribute to the HAD pathogenesis.
作者 董军 陆大祥 沈伟哉
机构地区 暨南大学医学院病理生理教研室 暨南大学医学院解剖教研室
出处 《病毒学报》 CAS CSCD 北大核心 2004年第1期34-39,共6页 Chinese Journal of Virology
关键词 艾滋病 HIV-1 海马脑片 LTP 蛋白激酶抑制剂 HIV 1 gp120 long term potentiation(LTP) H7 hippocampal slice
分类号 R512.91 [医药卫生—内科学]
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参考文献15

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同被引文献21

  • 1董军,陆大祥.HIV-1包膜糖蛋白V_3环对大鼠海马长时程增强效应的影响[J].中华微生物学和免疫学杂志,2004,24(3):235-238. 被引量：1
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病毒学报
2004年 第1期

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