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乳腺癌易感基因BRCA1研究进展 被引量：2

Advance in Researches on BRCA1
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摘要 BRCA1是目前所发现的最重要的乳腺癌易感基因之一,它在DNA损伤修复,细胞周期调节,基因的转录激活,染色质稳定性,细胞增殖等方面都起着重要作用。该文着重介绍近几年来BRCA1基础研究方面的进展,并讨论BRCA1在肿瘤发生、发展过程的作用。为BRCA1在临床上的应用提供理论依据。 BRCA1 is one of the most important breast cancer susceptibility genes. It plays key roles in DNA damage repair, cell cycle checkpoint regulation, gene transcription chromatin stability, and cell proliferation. In this paper, advance in basic researches on BRCA1 is reviewed, and the role of BRCA1 in cancer development and progression is discussed, that may facilitate potential clinical application of BRCA1.
作者 严景华 叶棋浓 黄翠芬
机构地区 军事医学科学院生物工程研究所
出处 《遗传》 CAS CSCD 北大核心 2004年第3期367-372,共6页 Hereditas（Beijing)
基金 国家自然科学基金(No.30370738)~~
关键词 BRCA1 DNA损伤修复 细胞周期调节 基因的转录激活 染色质稳定性 BRCA1 DNA damage repair cell checkpoint regulation gene transcription chromosome stability
分类号 R737.9 [医药卫生—肿瘤]
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参考文献59

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同被引文献23

  • 1许奕.BRCA1的研究进展[J].北京医学,2005,27(1):50-52. 被引量：14
  • 2谌容,陈敏,杨春贤,廖志华.基于SWISS-MODEL的蛋白质三维结构建模[J].生命的化学,2006,26(1):54-56. 被引量：24
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