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tmRNA的结构与功能 被引量：1

The Structure and Function of tmRNA
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摘要 tmRNA是一类具有类似tRNA分子和mRNA分子双重功能的小分子RNA,它在一种特殊的翻译模式——反式翻译模式过程中发挥重要作用。最近又发现它与基因的表达调控及细胞周期的调控等生命过程密切相关。因此,关于tmRNA的研究已经引起了研究者的高度重视,它将是RNA组学研究的一个重要内容。文章主要论述了近年来关于tmRNA结构和功能方面的一些研究进展。 tmRNA is a dual small RNA similar to a tRNA and a mRNA which plays an important role in an unusual mode of translation-trans translation. Recently, it was found that tmRNA had something to do with regulating gene expression and cell cycle. So the researchers have paid much attention on such area. Furthermore, it is an im- portant part in RNomics era. This article reviews the progress about the structure and function of tmRNA in recent years.
作者 田云 卢向阳 易克 唐勇军 陈惠明
机构地区 湖南农业大学生化与发酵工程实验室
出处 《遗传》 CAS CSCD 北大核心 2004年第3期409-413,共5页 Hereditas（Beijing)
关键词 TMRNA 反式翻译 SmpB蛋白 延伸因子-Tu 核蛋白S1 transfer-messenger RNA trans-translation SmpB protein elongation factor-Tu ribosomal protein S1
分类号 Q75 [生物学—分子生物学]
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参考文献25

  • 1Valle M, Gillet R, Kaur S, Henne A, Ramakrishnan V, Frank J.Visualizing tmRNA entry into a stalled ribosome. Science, 2003,300(5616): 127-130.
  • 2Williams K P. The tmRNA website: invasion by an intron.Nucleic Acids Research, 2002, 30(1): 179-182.
  • 3Zwieb C, Gorodkin J, Knudsen B, Burks J, Wower J. tmRDB (tmRNA database). Nucleic Acids Research, 2003, 31 (1):446-447.
  • 4Abo T, Inada T, Ogawa K, Aiba H. SsrA-mediated tagging and proteolysis of LacI and its role in the regulation of lac operon. The EMBO Journal, 2000, 19(14): 3762-3769.
  • 5Ranquet C, Geiselmann J, Toussaint A. The tRNA function of SsrA contributes to controlling repression of bacteriophage Mu prophage. Proc Natl Acad Sci USA, 2001, 98(18): 10220-10225.
  • 6Roche E D, Sauer R T. Identification of endogenous SsrATagged proteins reveals tagging at positions corresponding to stop codons. The Journal of Biological Chemistry, 2001, 276(30): 28509-28515.
  • 7Keiler K C, Shapiro L. tmRNA is required for correct timing of DNA replication in Caulobacter crescentus. Journal of Bacteriology, 2003, 185(2): 573-580.
  • 8Keiler K C, Shapiro L. tmRNA in Caulobacter crescentus is cell cycle regulated by temporally controlled transcription and RNA degradation. Journal of Bacteriology, 2003, 185 (6):1825-1830.
  • 9Zwieb C, Wower I, Wower J. Comparative sequence analysis of tmRNA. Nucleic Acids Research, 1999, 27(10): 2063-2071.
  • 10Ivanov P V, Zvereva M I, Shpanchenko O V, Dontsova O A,Bogdanov A A, Aglyamova G V, Lim V I, Teraoka Y, Nierhaus K H. How does tmRNA move through the ribosome?.FEBS Letters, 2002, 514(1): 55-59.

同被引文献14

  • 1Haebel P W, Gutmann S, Ban N. Dial tm for rescue: tmRNA engages ribosomes stalled on defective mRNAs. Curr Opin Struct Biol, 2004, 14(1): 58-65.
  • 2Hallier M, Ivanova N, Rametti A, Pavlov M, Ehrenberg M, Felden B. Pre-binding of small protein B to a stalled ribosome triggers trans-translation. J Biol Chem, 2004, 279(25): 25978-25985.
  • 3Yamamoto Y, Sunohara T, Jojima K, Inada T, Aiba H. SsrAmediated trans-translation plays a role in mRNA quality control by facilitating degradation of truncated mRNAs. FtNA, 2003, 9(4) :408-418.
  • 4Singh N S, Varshney U. A physiological connection between tmRNA and peptidyl-tRNA hydrolase functions in Escherichia coll.Nucleic Acids Res, 2004, 32(20): 6028-6037.
  • 5Sharkady S M, Williams K P. A third lineage with two-piece tmRNA. Nucleic Acids Res, 2004, 32(15) : 1-8.
  • 6Ivanov P V, Zvereva M I, Shpanchenko O V, Dontsova O A,Bogdanov A A, Aglyamova G V, Lim V I, Teraoka Y, Nierhaus K H. How does tmRNA move through the ribosome. FEBS Lett,2002, 514(1): 55-59.
  • 7Wower I K, Zwieb C, Wower J. Contributions of pseudoknots and protein SmpB to the structure and function of tmRNA in trens-translation. J Biol Chem, 2004, 279(52): 54202-54209.
  • 8Gutmann S, Haebel P W, Metzinger L, Sutter M, Felden B, Ban N. Crystal structure of the transfer-RNA domain of transfer-messenger RNA in complex with SmpB. Nature, 2003, 424(6949):699 -703.
  • 9Someya T, Nameki N, Hosoi H, Suzuki S, Hatanaka H, Fujii M,Terada T, Shirouzu M, Inoue Y, Shibata T, Kuramitsu S,Yokoyama S, Kawai G. Solution structure of a tmRNA-binding protein, SmpB, from Thermus thermophilus. FEBS Lett, 2003,535(1-3): 94-100.
  • 10Shpanchenko O V, Zvereva M I, Ivanov P V, Bugaeva E Y, Rozov A S, Bogdanov A A, Kalkum M, Isaksson L A, Nierhaus K H, Dontsova O A. Stepping tmRNA through the ribosome. J Biol Chem, 2005, 280(18) : 18368-18374.

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2004年 第3期

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