不同剂量乙肝疫苗免疫效果及安全性研究

Evaluation on immuno-effects and security of different doses of hepatitis B vaccine

目的 比较 3种不同剂量基因工程乙型肝炎疫苗的免疫效果。方法 对 130例 15～ 18岁健康人群的血清样品用酶联免疫法 (ELISA)检测HBsAg、抗 -HBs、抗 -HBc。 3项指标均为阴性者注射基因工程乙型肝炎疫苗 ,在全程免疫后 1年检测抗 -HBs阳转率及抗体几何平均滴度 (GMT)。结果 接种 3种不同剂量的基因工程乙型肝炎疫苗后均获得不同的免疫效果。结论 年龄在 15～ 18岁的健康人群 ,3次 2 0 μg基因工程乙型肝炎疫苗免疫效果明显优于 3次 10 μg、5 μg的基因工程乙型肝炎疫苗。

Objective To compare the immuno-effects of different doses of the genetic engineering hepatitis B vaccine. Methods Serum HBsAg , anti-HBs and anti-HBc were tested with ELISA in 130 samples of healthy persons aged from 15 to 18. The vaccine was injected to those whose 3 indexes were all negative. Anti-HBs positive rate and antibody geometric average drip degree(GMT) were tested after one year of vaccination. Results Different immuno-effects were obtained after different doses vaccination of the genetic engineering hepatitis B vaccine. Conclusion Results of 3-time vaccinations of 20 μg genetic engineering hepatitis B vaccine are obviously superior to the genetic engineering hepatitis B vaccine of 5 or 10 μg at the age of 15～18.