BLCAP蛋白表达与骨肉瘤恶性程度的关系

Relationship between expression of BLCAP protein and malignancy of osteosarcoma

目的 :了解BLCAP蛋白表达与骨肉瘤恶性程度的关系。方法 :采用SABC法 ,对临床收集骨肉瘤病理标本进行检测 ,观察BLCAP蛋白表达情况 ,结合临床随访结果 ,判断BLCAP蛋白表达与骨肉瘤恶性程度之间的关系。结果 :BLCAP蛋白在原发骨肉瘤组织中表达阳性率约为 6 5 .6 % ,而在复发性骨肉瘤组织中表达阳性率只有 2 5 .0 %。结论 :BLCAP蛋白表达水平与骨肉瘤恶性程度之间有一定的相关性 。

AIM: To study the relationship between expression of bladder cancer associated protein (BLCAP) and malignancy of osteosarcoma. METHODS: SABC method was applied to study the expression of BLCAP protein in osteosarcoma, according to clinical results, to analize the prognosis value of BLCAP protein in osteosarcoma. RESULTS: The positive rate of BLCAP protein in primary osteosarcoma was 65.6%, much higher than that in recurrent osteosarcoma, which was 25.0%. CONCLUSION: It may be helpful for evaluating the prognosis of osteosarcoma to study the relationship between expression of BLCAP protein and malignancy of osteosarcoma.