膀胱癌患者染色体畸变及SCE的研究

THE RESEARCHES OF CHROMOSOMAL ABERRATION AND SISTER CHROMATID EXCHANGE IN PATIENTS WITH BLADDER CANCER

作者对19例膀胱癌患者和16例正常人外周血淋巴细胞染色体畸变和SCE进行了研究。结果表明膀胱癌患者染色体总畸变率、断裂及裂隙、脆性位点的表达、四倍体、着丝粒后期相以及SCE率都明显高于正常人。对以脆性位点表达率和SCE率为指标检测群体中,尤其是高危群体中肿瘤易患性个体的可能性进行了讨论。

The researches of chromosomal aberration and sister chrbmatidexchange (SCE)were performed on 19 patients with bladder and 16 normal controls. The results suggest that the rate of all chromosomal aberration, chromosomal break and gap, expression of fragile site, tetraploid, anaphase-like, rate of SCE are highhter in the patients than that in the controls. The possibility screening individuals susceptible to tumor in population,especifically in high risk population, was discussed.