食物与鼻咽癌——广州市居民鼻咽癌病例对照研究

DIET AND NASOPHARYNGEAL GARCINOMA:A CASE -CONTROL STUDY IN GUANGZHOU,CHINA

1983年3月1日至1985年8月31日对经病理确诊,年龄在50岁以下的广州市居民鼻咽癌新发病例进行病例一对照研究。应用Logistic多因素回归分析方法来分析各项数据,结果如下: 1.在各个被调查时期,母亲和对象咸鱼摄入经常度与鼻咽癌发病有显著相关。 2.除咸鱼外,儿童期进食其他五种腌制食品或酱油表明与鼻咽癌发病呈显著相关。这五种腌制食品为鱼露、咸虾酱、腐乳、陈皮梅、嘉应子。而发病前三年进食这些食品显示与鼻咽癌发病无关。 3.在各个被调查时期,病例组较对照组更少进食新鲜蔬菜和水果,显示与鼻咽癌发病有相关。 4.检测咸鱼、鱼露、咸虾酱、腐乳、陈皮梅、嘉应子、西红柿对鼻咽癌发病的作用,有三种食物显示其在鼻咽癌发病上是作为独立的危险因素,它们是咸鱼、腐乳、陈皮梅,而西红柿则为保护因素。 综上述可见:从多个流行病学调查和实验室研究均表明:进食含有亚硝胺类致癌物的咸鱼与鼻咽癌发病密切相关,而且在儿童期越年幼进食,相对危险性越大。

We have conducted an interviews on 306 histplogicalfy confirmed incident cases of nasopharyngeal carcinoma (NPC) occurring in residents of Guangzhou City, China, who were under the age of 50 years, and an equal number of age-, sex-, and neighborhood-matched control-. We have also interviewed 110 mothers of patients under age 45 years and 139 mothers of controls who were atched to patients under age 45 years, to obtain informations on childhood exposures of studied subjects. Exposure to salted fish, whether in adulthood or in childhood, was signifcantly associated with an increased risk of NPC. The association was strongest for exposure during weaning, and exposures at all other periods were no longer related to NPC risk after adjustment for exposure during weaning. Besides salted fish, childhood, exposure to 5 other preserved foods(fermented) fish sauce, salted salted shrimp paste, moldy bean curd, and 2 kinds of preserved plum) was significantly related to NPC, and the effects were independent of salted fish exposure.F'inally, cases ingesed significantly less fresh vegetables and fruits than controls, especially during early childhood, and the differences were not explained by their differing consumption pattern of salted fish and other preserved foods.