甘草甜素等对黄曲霉毒素B_1致大鼠肝癌作用的影响

EFFECTS OF GLYCYRRHIZIN, SILYMARIN, CITRUS PEAL AND JUICE ON AFLATOXIN B_1-INDUCED HEPATOCARCINOGENESIS IN RATS

应用黄曲霉毒素B_1(AFB_1)致大鼠肝癌作用的短期体内实验模型,研究两种治疗慢性乙肝的中药制剂甘草甜素和水飞蓟素及可食植物柑果之果皮、果汁对AFB_1致肝癌作用的影响。发现甘草甜素具有明显抑制AFB_1诱发肝癌前病变的作用。文中对甘草甜素的抑制机理进行了讨论。

Aflatoxin Bt (AFB1) contamination in foods is a serious problem in some areas with high incidence of primary liver cancer (PLC). Seeking for the chemopreventive agents which may inhibit AFB1 hepatocarcinogenesis is necessary. For this purpose, glycyrrhizin, silymarin, as well as the abstracts of citrus peal and juice were tested for their effects on AFB1-induced precancerous γ-glutamyltranspeptidase(γ-GT)positive hepatocellular foci in rats by using by the short term γ in vivo test model of AFB1 hepatocarainogene-sis. It was foud that glycy rrhizin possesses a remarkable inhibitory effect on the AFB1 hepatocar cinogenesis in rats It B interesting that glycyrrhizin is clinically effective for the treatment of chronic viral hepatitis, suggesting that glycyrrhizin is very usefull in practice because AFB1 contamination and hepatitis B virus infection always coexist in the very high incidence areas for PLC.