胃癌患者SOD活性与LPO含量观察

THE OBSERV ATION OF SOD ACTIVITY AND LPO CONTENT ON THE PATIENTS OF GASTRIC CANCER

本文作者观察34例胃癌术前病例SOD活性和LPO含量。和36例正常人比较,胃癌患者红细胞SOD活性下降,血清LPO含量升高,两者呈负相关,城市和农村病例之间无地区差别。胃癌病例Hb也低于对照组。结果提示:自由基反应增强,氧化与抗氧化代谢过程紊乱,可能是胃癌发病过程的重要因素。

The activity of su peroxide dismutase (SOD) and the content of lipid peroxide(LPO) in 24 cases of gastric cancer were tested. As compared with control group, a lower activity of erythfocyte SOD and a higher serum content of LPO in the patients with gastrc cancer was observed. A negative correlation presented between these two para meters The dfference between the cases from the city and from the country side was not obvious. The content of hemoglobin was also lower in the patients than that in the control group The results suggested that in the patients of gastric cancer enhanced free-radical reaction decreased SOD activity and increased LPO content, may lead to metabolic disorder of oxidation and antioxidation. These changes may be an important factor in the pathogen-etic processes of gastrc cancer.