消炎痛和139—3对手术前后肺癌患者细胞免疫功能影响的动态研究

THE INFLUENCE OF FLUOR OURACIL POLYPHASE LIPOSOME AND INDOMETHACIN ON CELL-MEDIATED IMMUNITY OF LUNG CANCER PATIENTS DURING PRE-AND POSTOPERATIVE PERIOD

肿瘤诱导产生的各种免抑因子可强烈抑制细胞免疫。本试验是考察消炎痛及与139—3合用对癌症病人免疫功能的影响。 将肺癌病人随机分三组,分别以①单纯手术:②139—3+手术,③消炎痛+139—3+手术治疗,测定手术前后不同时间各项免疫指标。 结果显示肺癌病人细胞免疫状态显著降低,与分期相关而与组织分型无关,麻醉手术会进一步损伤机体免疫,139-3能提高免疫机能,保护它不被手术进一步损伤及促进其较快恢复,若与消炎痛合用则协同效果明显。

The purpose of this paper is to determine whether indomethacine(IND) and combined with fluorouracil plyphass liposome (139-3) can stimulate the immunity in lung cancer patients, especially in pre and postoperative perbd.The abmitted patients were randomly divided in three groups: (1) Operation alone, (2) 139-3 was given before operation, (3) IND and 139 - 3 were given at first then followed by operation. Six immunological criteria were determined.The result showed that the cell-mediated immunity (CMI) in lung cancer patients was lower than that in normal controls. Anaesthesia and operation can further suppress the impaired CML 139 - 3 possessed the action of:(1) enhancing CMI, )2) protecting it from further damage by anaesthesia and operation, (3) promoting its' recovery after operation. Indome-thacin could promote the CMI in lung cancer patients. The two drugs showed synergic effects on CMI