胃粘膜损伤程度与胃癌发生的关系

THE TRAUMATIC DEGREE OF GASTRIC MUCOSA AND PATHOGENESIS OF GASTRIC CANCER

选择四种日常生活中经常遇到的胃粘膜损伤因素——4％牛磺胆酸钠、40％酒精、15％高张盐水及60℃热糊,根据其对大白鼠胃粘膜的损伤程度,判定其损伤指数分别为1.00±0.53、1.75±0.46、2.50±0.53及3.00±0.53,结合浓度为100μg/ml的致癌剂MNNG自由饮用,共20周,诱发胃癌,结果胃癌的发生率分别为11.9％、14.7％、24.1％及34.6％。统计学分析表明,胃粘膜损伤指数与胃癌发生率呈正直线相关。 (γ=0.9551,P<0.05)初步揭示了胃癌发生与胃粘膜在一定范围内的损伤程度紧密相关。

4 groups of rats were received intermittent intragastric irrigation of the following 4 kinds of solutions-4 % sodium taurocholate, 40% alcohol, 15% hypert-onic saline and 60℃hot paste 1.5ml twice a week for 20weeks ,respectively, served as gastric mucosal traumatic factors in order to induce mild, moderate and severe mucosal damages. 100ug/ ml MNNG in drinking water was also administered during the same periodl Another 21 months were followed for observation. The traumatic degree of gastric mucosa was measured according to pathological changes i nyolved in various layers of the mucosal damages. Their traumatic indices were as follows: 1.00±0. 53, 1.75±0.46, 2. 50±0. 53ands. 00±0. 53. The incedence rate of gastric cancer was 11.9% , 14.7%, 24.1% and 34.6% respectively, and had positive correlation with above indices(r=0. 9551, p <0. 65). These observation suggested that the pathogenesis of gastric cancer might be closely related to the traumatic degree of gastric mucosa.