汕头市食管癌高低发区居民膳食及尿中亚硝胺的前体物质含量检测

DETERMINATION OF THE PRECURSORS OF N-NITROSMINE IN ONE DAY MEAL AND MORNING URINE DERIVED FROM HIGH-AND LOW-RISK AREA FOR OESOPHAGEAL CARCINOMA IN SHANTOU

亚硝胺可由其前体物质亚硝酸盐及二级胺在体内合成。本实验测定了29例汕头市食管癌高发区居民一日膳食中摄入及次日晨尿中排出亚硝胺前体物质的量,并以28例低发区陆丰县的居民作对照。结果发现,高发区居民一日膳食中硝酸盐含量高于低发区(P<0.01);次日晨尿中亚硝酸盐,二级胺排泄含量低于低发区(P<0.01)。提示高发区人群体内合成亚硝胺较多,可能与食管癌的发生有关。

N-Nitrosamine can be formed in vivo by the interaction of nitrites with secondary amines . The contents of the precursors of N-Nitrosmine in one day meal and next morning urine derived from residents in high-(29 cases) and low-risk (28 cases) for oe-sophageal carcinoma in Shantou area were measured in the present study. The results showed that the contents of Nitrate in one day meal from high-risk area are significantly higher than those from low-risk area (P<0.01) . The excretions of nitrite and secondary amines in the urine from high-risk area significantly lower than those from low-risk area(P<0. 01). It is suggested that endogenous formation of N-Nitrosamine in the residents of high-risk area is higher, and this may be related to the etiology of oesophageal carcinoma.