肺癌高危人群特征与阻断治疗效应

CHARACTERISTICS IN THE HIGH RISK POPULATION OF LUNG CANCER AND EFFECTIVE ANALYSIS OF THE CHEMOPREVENTIVE TREATMENT OF THE PRECANCEROUS LESIONS (SEVEN YEARS FOLLOW-UP RESULTS FOR 592 SUBJECTS IN HUNAN REALGAR MINE)

本文报告肺癌高危人群592人7年随访结果。痰检发现支气管上皮细胞中或重度非典型增生组肺癌发病率为正常组的2.31倍,轻度增生组为正常组的1.30倍;对3组的群体特征与肺癌组进行了比较分析,在人群维生素A的含量以肺癌组最低,且发癌后比发癌前有降低趋势,当补充维甲类药后有抑癌作用,3年服药后的抑癌率为75.69％,停药4年后抑癌率为69.70％。

This paper reported the results of the seven years follow-up for 592subjects of the high risk population of lung cancer in Hunan realgar mine. It was found that the incidence rate of the moderate or severe hyperplasia groups was 2.31 times higher than that of normal group, the incidence rate of the squamous metaplasia and mild hyperplasia group was 1. 30 times as high as normal group. In the moderate or severe hyperplasia groups, chemopreventive treatment of the precancerous lesion was carried out by giving R1 (N-P-ethoxycarbonyphenyl-retinamide) & R2 (N-P-carbonyphenyl-retinamide) which were retinoids .synthesized by the Institute of Materia Medica, Chinese Academy of Medical Scie-ences . The inhibition rate of lung cancer in the treated groups was 75. 69% after three years treatment, and was still 69-70% after four year of discontinuation of treatment. The results of investigation showed that the combined effect of arsenide and smoking was the major risk factor of lung cancer in Hunan realgar mine, the relative risk (RR) was 14.8 and the average contents of serum vitamin A in the patients who suffered from,lung cancer was declined. It is indicated that the vitamin A content in population of Hunan realgar mine was relatively deficienty. However, we think that boosting the R1& R2 dose and continuing the rtreatment time may achieve more satisfactory effect.