摘要
丙亚胺、乙双吗啉和丙双吗啉对Lewis肺癌原位肿瘤生长和肺转移有抑制作用,且疗效相似。丙亚胺或丙双吗啉大剂量间歇给药也有抗Lewis肺癌生长的作用。丙亚胺不影响柔红霉素对Lewis肺癌的作用,却能与博莱霉素产生协同效应。丙奴吗啉能明显降低荷瘤鼠血清中唾液酸含量。
Razoxane, Bimolane and Probimane could inhibit the growth of Lewis lung carcinoma including primary tumor and metastatic foci. The inhibitory rates of the a above mentioned three compounds were similar each to others. Razoxane (10mg.kg-1) and Probimana (20mg.kg-1) were also effective aogainst Lewis lung carcinoma by administration 3 times daily on day 1,5,9 after tumor inoculation. They did not alter the antitumor activity of daunorubicin, . but increased the antitumor effect of bleomycin on Lewis lung carcinoma. Probimane colud also decrease the serum sialic acid level in mice bearing tumors.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1993年第6期496-499,共4页
Chinese Journal of Cancer
关键词
丙亚胺
LEWIS肺癌
肿瘤转移
肺肿瘤
Razovxane Probimane Lewis lung carcinoma tumor metastased dauno rubicin bleomycin sialic acibd
