慢性胃炎结节状改变与幽门螺杆菌感染的关系研究

Study on the relation between nodular gastritis and Helicobacter pylori infection

目的 探讨慢性胃炎结节状改变与幽门螺杆菌 (Hp)感染的关系。方法 对 2 0 0 1～2 0 0 2年中胃镜检查发现的慢性胃炎结节状改变患者进行Hp检测 ,对Hp阳性患者 ,进行Hp根除治疗 ,随访 6个月 ,观察其胃镜下的改变。结果 4 939例胃镜检查患者中共发现 1 3例慢性胃炎结节状改变 ,占检查总人数的 0 2 6 %。平均年龄 2 9岁 ,均为女性患者。主要症状均为上腹部疼痛。所有患者均有Hp感染。Hp根除成功后 ,症状和胃镜下结节状表现消失 ,病理证实胃黏膜下淋巴滤泡也随之消失。结论 慢性胃炎结节状改变可作为Hp阳性胃炎的内镜下的表现之一。

Objective To investigate the association between the nodular gastritis and the eradication of Helicobacter pylori .Methods To the patients with nodular gastritis discovered by gastroendoscopy during 2001～2002, detection of Helicobacter pylori and eradication of it if positive, were performed then followed up after 6 months by endoscopies.Results From 4939 cases of endoscopy thirteen cases of female nodular gastritis were diagnosed, accounted to 0 26% of the total cases examined. The age of patients ranged from 14～49 years, with mean age 29 years.The main symptom is epigastralgia. All cases were found affected with H.pylori . After H.pylori eradication, there is disappearance of the nodular appearance of the gastric antrum under endoscopies and disappearance of the gastric submucosal lymphoid follicles under histological examination.Conclusion Nodular gastritis is the very important manifestation having a high positive predictive value in H.pylori infection.