期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Ⅳ型胶原酶与2型糖尿病大血管病变

下载PDF
导出
摘要 2型糖尿病合并大血管病变时,无论在大血管壁或是血浆中Ⅳ型胶原酶均存在较高水平的表达,高水平的Ⅳ型胶原酶可促进动脉粥样硬化的发展,氧化应激和细胞因子在其中起着重要作用。降低Ⅳ型胶原酶成为目前糖尿病治疗的新靶点。
作者 潘勇翔 蒋绿芝
机构地区 昆明医学院第二附属医院内分泌科
出处 《国外医学（内分泌学分册）》 2004年第B05期23-25,共3页 Foreign Medical Sciences(Section of Endocrinology)
关键词 Ⅳ型胶原酶 2型糖尿病 并发症 大血管病变 细胞因子 氧化应激 细胞外基质
分类号 R587.2 [医药卫生—内分泌]
  • 相关文献

参考文献15

  • 1Pasterkamp G,Schoneveld AH,Hijnen DJ,et al.Atherosclerotic arterial remodeling and the localization of macrophages and matrix metalloproteinases 1,2 and 9 in the human coronary artery.Atherosclerosis,2000,150:245-253.
  • 2Karamessinis PM,Tzinia AK,Kitsiou PV,et al.Proximal tubular epithelial cell integrins respond to high glucose by altered cell-matrix interactions and differentially regulate matrixin expression.Lab Invest,2002,82:1081-1093.
  • 3Graig RG,Yu Z,Xu L,et al.A Chemically modified tetracycline inhibits streptocin-induced diabetic depression of skin collagen synthesis and steady-state type Ⅰ procollagen mRNA.Biochim Biophys Acta,1998,1402:250-260.
  • 4Blankenberg S,Rupprecht HJ,Poirier O,et al.Plasma concentrations and genetic variation of matrix metalloproteinase 9 and prognosis of patients with cardiovascular disease.Circulation,2003,4:1579-1585.
  • 5Suzuki D,Yagame M,Kim Y,et al.Renal in situ hybridization studies of extracellular matrix related molecules in type 1 diabetes mellitus.Nephron,2002,92: 564-572.
  • 6Mach F,Schonbeck U,Fabunmi RP,et al.T lymphocytes induces endothelial cell matrix metalloproteinase expression by a CK 40L-dependent mechanism.Am J Pathol,1999,154:229-238.
  • 7Xu XP,Meisel SR,Ong JM,et al.Oxidized low-density lipoprotein regulates matrix metalloproteinase-9 and its tissue inhibitor in human monocyte-derived macrophages.Circulation,1999,3: 993-998.
  • 8Bennett MR.Apoptosis of vascular smooth muscle cells in vascular remodelling and atherosclerotic plaque rupture.Cardiovasc Res,1999,41:361-368.
  • 9Moreno PR,Murcia AM,Palacios IF,et al.Coronary composition and macrophage infiltration in atherectomy specimens from patients with diaberes mellitus.Circulation,2000,102:2180-2184.
  • 10Ebihara I,Nakanura T,Shimada N,et al.Increased plasma metalloproteinase-9 concentrations precede development of microalbuminuria in non-insulin-dependent diabetes mellitus.Am J Kidney Dis,1998,10:544-550.

二级参考文献5

  • 1Zhang BP, Ye S, Herrmann SM, et al. Functional polymorphism in the regulatory region of gelatinase B gen in relation to severity of coronary atherosclerosis. Circulation, 1999,99:1788-1794.
  • 2Bennett MR. Apoptosis of vascular smooth muscle cells in vascular remodelling and atheroslerotic plaque rupture. Cardiovasc-Res, 1999,41 :361-368.
  • 3Rekhter MD, Hicks GW, Brammer DW, et al. Hypercholesterolemia causes mechanical weakening of rabbit atheroma: local collagen loss as a prerequisite of plaque rupture. Cire-Res ,2000,86 : 101-108.
  • 4Xu XP, Meisel SR, Ong JM, et al. Oxidized low-density lipoprotein regulates matrix metalliproteianse-9 and its tissue inhibitor in human monocyte-derived macrophage. Circulation, 1999 24:993-998.
  • 5Mach F, Schonbeck U,Bonnefoy JY, et al. Activation of monocyte/macrophage functions related to acute atheroma complication by ligation of CD40. Circulation, 1997,96:396-399.

共引文献31

国外医学（内分泌学分册）
2004年 第B05期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部