摘要
磺脲类药物是治疗2型糖尿病的常用药物,近年来有许多临床研究显示其对心血管系统可能有不良影响。如:接受磺脲类药物治疗者更多倾向于发生心肌梗死前心绞痛,其发生心肌梗死时心肌酶谱的增高幅度小于其他患者。磺脲类药物治疗对心肌功能有不良影响,但其对心血管事件预后的影响,不同的研究结论不尽相同。对有心血管疾病的糖尿病患者,治疗应慎用磺脲类药物。
出处
《国外医学(内分泌学分册)》
2004年第3期199-201,共3页
Foreign Medical Sciences(Section of Endocrinology)
参考文献18
-
1Aronow WS, Ahn C. Incidence of new coronary events in older persons with diabetes mellitus and prior myocardial infarction treated with sulfonylureas, insulin, metformin, and diet alone. Am J Cardiol, 2001,88:556-557.
-
2Jimenez-Navarro M, Gomez-Doblas JJ, Hernandez-Garcia JM, et al. Docs angina pectoris the week before protect against first acute myocardial infarction in patients with diabetes mellitus? Am J Cardio1,2002,90:160-162.
-
3Garratt KN, Brady PA, Hassinger NL, et al. Sulfonylurea drugs increase early mortality in patients with diabetes mellitus after direct angioplasty for acute myocardial infarction. J Am Coll Cardiol, 1999,33:119-124.
-
4del Valle HF, Lascano EC, Negroni JA, et al. Glibenclamide effects on reperfusion-induced malignant arrhythmias and left ventricular mechanical recovery from stunning in conscious sheep. Cardiovasc Res,2001,50:474-485.
-
5Riddle MC. Editorial: sulfonylureas differ in effects on ischemic preconditioning-is it time to retire glyburide? J Clin Endocrinol Metab,2003,88: 528-530.
-
6Halkin A, Roth A, Jonas M, et al. Suffonylureas are not associated with increased mortality in diabetics treated with thrombolysis for acute myocardial infarction. J Thromb Thrombolysis, 2001,12:177 - 184.
-
7Gustsfsson I, Hildebrandt P, Seibaek M, et al. Long-term prognosis of diabetic patients with myocardial infarction: relation to antidiabetic treatment regimen. Eur Heart J,2000,21:1937-1943.
-
8Brady PA, AI-Suwaidi J, Kopecky SL. Sulfonylureas and mortality in diabetic patients after myocardial infarction. Circulation, 1998,97: 709-710.
-
9Moreno R, Garcia E, Zamorano J, et al. Acute myocardial infarction in diabetic patients. Are we actually doing bad? Eur Heart J,2001,22:1359-1361.
-
10Lee TM, Chou TF. Impairment of myocardial protection in type 2 diabetic patients. J Clin Endocrinol Metab, 2003,88: 531-537.
同被引文献23
-
1杨文英.磺脲类药物应用专家共识[J].国外医学(内分泌学分册),2004,24(4):255-259. 被引量:75
-
2Fisman E Z,Tenenbaum A,Boyko V,et al.Oral antidiabetic treatment in patient with coronary disease:time-related increased mortality on com-bined glyburid/metformin therapy over a 7.7 year followup[J].Clin Cardiol,2001,24:151-158.
-
3Bell DSH.A comparison of agents used to manage type 2 diabetes mellitus-Need for reappraisal of traditional approaches[J].Treat Endocrinol,2004,3:67-76.
-
4Ovalle F,Bell D S H.Clinical evidence of thazolidinedione-induced improvement of pancreatic β-cell function in patient with type 2 diabetes mellitus[J].Diabetes Obes Metab,2002,4:56-59.
-
5Stevens R J, Coleman R L, Adler AI,et al.Risk factors for myocardial infarction case fatality and stroke case fatality in type 2 diabetes: UKPDS 66[J].Diabetes Care,2004,27:201-207.
-
6Stratton I M,Adler A I,Neil H A W,et al.Association of glycaemia with macrovascular and micravascular complications of type 2 diabetes (UKPDS 35):Prospective observations study[J].BMJ,2000,321:405-412.
-
7Khaw K T,Wareham N,Luben R,et al.Glycates haemoglobin,diabetes,and mortality in men in Norfolk cohort of European Prospective Investigation of Cancer and Nutrition(EPIC-Norfolk)[J].BMJ,2001,322:15-18.
-
8ACE guidelines:American College of Endocrinology consensus statement on guidelines for glycemia control[J].Endocr Pract,2002,8(suppl 1):6-11.
-
9Fonseca V,Rosenstock J,Patwardhan R,et al.Effect of metformin and rosiglitazone combination therapy of in patient with type 2 diabetes mellitus:A randomized controlled trial[J].JAMA,2000,283:1695-1702.
-
10Hsueh W A,Lyon C J,Quinones M J.Insulin resistance and the endothelium[J].Am J Med,2004,117:109-117.
-
1赵亚臣,李玉龙,张云添.扩血管药—卡维地洛的应用[J].黑龙江医药,2004,17(2):144-145.
-
2李肇仁.新型扩血管药——卡维地洛[J].新药与临床,1990,9(1):36-38. 被引量:5
-
3张勇,Emmanuel NALINE,陈红专,Charles ADVENIER.M_2受体对人支气管平滑肌功能性拮抗的影响[J].上海第二医科大学学报,2004,24(9):723-725. 被引量:2
-
4冯恩民,孙华,夏延贞.氢化可的松对兔脓毒症早期心肌功能的影响[J].中国危重病急救医学,2009,21(12):719-721. 被引量:10
-
5李健康,李君灵.牛磺酸对骨骼肌功能的影响研究进展[J].中国运动医学杂志,2011,30(11):1056-1060. 被引量:1
-
6许爱军,李军,段世明.新型肌松药在小儿麻醉中的应用进展[J].国外医学(麻醉学与复苏分册),2003,24(1):29-32. 被引量:4
-
7段立华,任雷鸣.多沙唑嗪对映体对大鼠离体心脏心肌活力的作用[J].中国药理学与毒理学杂志,2012,26(1):16-20.
-
8王永,罗金燕.红霉素对狗ODDI据约肌功能的影响[J].中华消化杂志,1997,17(S1):37-37.
-
9兰秀聪,郑桂爱,林建军.环磷腺苷葡胺注射液治疗婴幼儿轮状病毒肠炎并发心肌功能损害疗效观察[J].海峡药学,2009,21(5):177-178. 被引量:5
-
10李和敏,亢泽坤,张燕梅.5-单硝异山梨酯针剂静脉滴注对急性心肌梗死患者心功能的影响[J].河北医药,2003,25(9):652-653.