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parkin基因与帕金森病 被引量:1

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作者 杨卉 陈生弟
出处 《中华老年医学杂志》 CAS CSCD 北大核心 2004年第5期353-355,共3页 Chinese Journal of Geriatrics
基金 脑功能和脑重大疾病的基础研究项目(G19990 5 40 0 8)
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  • 1Kitada T,Asakawa S,Hattori N,et al.Mutation in the parkin gene cause autosomal recessive juvenile parkinsonism.Nature,1998,392:605-608.
  • 2Shimura H,Hattori N,Kubo S,et al.Familial Parkinson disease gene product,parkin,is a ubiquitin-protein ligase.Nat Genet,2000,25:302-305.
  • 3Mcnaught KS,Olanow CW.Proteolytic stress:a unifying concept for the etiopathogenesis of Parkinson's disease.Ann Neurol,2003,53(Suppl)3:S73-S84.
  • 4Gu WG,Abbas N,Lagunes MA,et al.Cloning of rat parkin cDNA and distribution of parkin in rat brain.J Neurochem,2000,74:1773-1776.
  • 5Kahle PJ,Leimer U,Haass C.Does failure of parkin-mediated ubiquitination cause juvenile parkinsonism? Trends Biochem Sci,2000,25:524-527.
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  • 7Kubo SI,Kitami T,Noda S,et al.Parkin was associated with synapse vesicle.J Neurochem,2001,78:42-54.
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  • 9Abbas N,Lucking CB,Ricard S,et al.A wide variety of mutation in the parkin gene are responsible for autosomal recessive parkinsonism in Europe.Hum Mol Genet,1999,8:567-574.
  • 10Periquet M,Lucking C,Vaughan J,et al.Origin of the mutations in the parkin gene in Europe:exon rearrangements are independent recurrent events,whereas point mutations may result from Founder effects.Am J Hum Genet,2001,68:617-626.

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