丹参和神经生长因子并用对急性脊髓损伤患者血液流变学和脂质过氧化的保护作用

Protective effects of danshen combined with nerve growth factor on the hemorheological indexes and lipid peroxidation in patients with acute spinal cord injury

目的:研究静脉注射丹参结合局部应用神经生长因子(NerveGrowthFactor,NGF)对急性脊髓损伤患者血液流变学和脂质过氧化的影响。方法:48例急性脊髓损伤(acutespinalcordinjury,ASCI)患者分为甲泼尼龙犤甲基强的松龙(Methylprednisolone,MP)犦治疗组,丹参治疗组,NGF治疗组和丹参结合NGF治疗组。治疗前和治疗后24h,检测患者血液流变学指标:全血黏度低、中、高切变值、纤维蛋白原(fibrinogen,Fib)、红细胞聚积指数(redcellaccumulationindex,RAI)、红细胞变形指数(redcelldistortionindex,RDI)和超氧化物歧化酶(SOD)、丙二醛(MDA)水平。结果:丹参结合NGF治疗后,患者较其他治疗组血液流变学指标明显改善,SOD活性增高,MDA含量下降,并有显著性差异。结论:静注丹参结合局部应用NGF治疗可改善患者微循环,抑制脂质过氧化,对脊髓损伤起保护作用,疗效较MP好。

AIM:To study the effects of danshen injected via vein combined with local application of nerve growth factor(NGF) on hemorheological indexes and lipid peroxidation in patients wtih acute spinal cord injury(ASCI). METHODS:Forty eight patients with ASCI were divided into four groups with 12 patients in each group,methylprednisolone(MP) group,danshen group,NGF group and combination group(danshen+NGF).Hemorheological indexes,including low,middle and high shear values of whole blood viscosity,fibrinogen,red cell accumulation index and red cell distortion index,the activity of superoxidase(SOD) and the content of malondialdehyde(MDA) were measured before and 24 hours after treatment. RESULTS:Compared with the other groups,the hemorrheological indexes were improved,the SOD activity was increased,and the MDA content was decreased in the combination group after treatment,with significant difference. CONCLUSION:Injection of danshen via vein combined with local application of NGF can improve microcirculation,restrain lipid peroxidation and protect SCI in patients,and has better therapeutic effects than MP.